Atomic structures of FUS LC domain segments reveal bases for …
2018年4月2日 · FUS contains an N-terminal IDR characterized by amino acid sequences with low complexity, FUS LC, that is known to be important for the dynamic assembly of FUS. In vitro, …
Spatiotemporal Control of Intracellular Phase Transitions Using …
2017年1月12日 · Here, we introduce an optogenetic platform that uses light to activate IDR-mediated phase transitions in living cells. We use this “optoDroplet” system to study …
Light-activated macromolecular phase separation modulates
2023年3月31日 · Two prototypical domains, the N-terminal IDR of the FET (FUS, EWS, and TAF15) family protein FUS (FUS N) and the C-terminal IDRs of the bromodomain protein …
pcDNA3.1-GFP-FUS-IDR - Addgene
Expression of eGFP fused to a intrinsically disordered regions of the FUS protein
Nature | 相分离促进染色质环结构的形成以及癌症的发生 - 知乎
2021年6月23日，北卡罗来纳大学教堂山分校 (University of North Carolina at Chapel Hill) 由 Greg Wang (王刚)和 Douglas H. Phanstiel 领导的两个研究团队在Nature杂志上在线发表题为 Phase …
Specific multivalent molecules boost CRISPR-mediated ... - Nature
2024年8月22日 · CRISPR/Cas-based transcriptional activators can be enhanced by intrinsically disordered regions (IDRs). However, the underlying mechanisms are still debatable. Here, we …
生命学院方晓峰实验室合作发现凝聚体可以内陷和切割细胞内膜-清 …
2024年10月16日 · 研究团队进一步提供了很强的遗传学证据：在缺失escrt的植物中过表达可以形成凝聚体的fus-idr-free1，发现能够很大程度上实现mvb内ilv的形成。
Condensation of the fusion focus by the intrinsically disordered …
2022年11月7日 · Here, we show that the regulatory N terminus of Fus1 contains an intrinsically disordered region (IDR) that mediates Fus1 condensation in vivo and forms dense assemblies …
Disorder-mediated interactions target proteins to specific …
2024年9月19日 · Here, we perform a comparative analysis of proteins partitioned into two distinct condensates formed by either MED1 IDR or the IDR of fused in sarcoma (FUS IDR).
相分离可通过调控染色质三维结构重组促进细胞命运转变
2021年5月27日 · 为了进一步验证OCT4相分离调控TAD重组的因果关系，研究人员还对突变型OCT4进行了IDR融合的相分离恢复（rescue）实验。 该方法是将FUS蛋白的IDR区域融合到 …
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