2022年12月1日 · Herein we describe a platform method to study the charge heterogeneity of adeno-associated virus (AAV) capsid proteins. The method, based on imaged capillary …

2023年3月10日 · In the present study, we developed simple, one-step sample preparation and charge-based VP separation using imaged capillary isoelectric focusing (icIEF) for monitoring …

2023年5月3日 · In this study, we describe an icIEF immunoassay method for AAV analysis that is 90 times more sensitive than native fluorescence icIEF. This icIEF immunoassay provides …

In the present study, we developed simple, one-step sample prep-aration and charge-based VP separation using imaged capillary isoelectric focusing (icIEF) for monitoring AAV products. The …

For AAV, capsid deamidation is a CQA. An icIEF method was able to be developed; however, it is unclear which peaks represent which capsid proteins and/or acidic

The study described the development of an imaged cIEF (icIEF) platform method on the MauriceTM system for charge heterogeneity analysis of AAV capsid proteins, which in turn …

Imaged capillary isoelectric focusing (icIEF) and capillary electrophoresis sodium dodecyl sulfate (CE-SDS) are two powerful methods to respectively characterize charge heterogeneity and …

2021年6月7日 · This 15-minute Tech Talk focuses on Adeno-associated virus (AAV) Empty and Full separation using the imaged cIEF method with the Maurice system. Dr. Wei showcases …

2023年6月8日 · Here, we present a robust icIEF method leveraging simplified one-step sample preparation to profile charge variants of AAV VPs. This rapid capillary assay is suitable for …

Here, we present a robust icIEF method leveraging simplified one-step sample preparation to profile charge variants of AAV VPs. This rapid capillary assay is suitable for monitoring charge …