2024年12月25日 · IFITM1 (Interferon Induced Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with IFITM1 include Influenza and West Nile Virus. Among its related pathways are Cytokine Signaling in Immune system and …

Interferon-induced transmembrane protein 1 is a protein that in humans is encoded by the IFITM1 gene. [3] [4] IFITM1 has also recently been designated CD225 (cluster of differentiation 225). This protein has several additional names: fragilis (human homolog of the mouse protein), IFI17 [interferon-induced protein 17], 9-27 [Interferon-inducible ...

2024年4月22日 · The function of interferon-induced transmembrane protein-1 (IFITM1) in EBV infection of ECs remains elusive. Here we report that IFITM1 inhibits EphA2-mediated EBV entry into ECs.

IFITM1 suppression blocks proliferation and invasion of aromatase inhibitor-resistant breast cancer in vivo by JAK/STAT1-mediated induction of p21. Compared with CD10, IFITM1 has superior performance distinguishing endometrial stroma of adenomyosis from mesenchyma surrounding invasive endometrial adenocarcinoma.

2024年12月16日 · 该研究揭示了IFITM1（干扰素诱导的跨膜蛋白1）在竞争性抑制EB病毒（Epstein-Barr Virus, EBV）感染上皮细胞过程中的关键作用及其分子机制，为EB病毒及相关疾病的早期筛查、预防和治疗提供了全新的思路。

IFITM1 acts through the negative regulatory effect of CAV1 on the EGFR pathway and thus affects the EMT signature and migration (164, 183). IFITM1 was defined as a tight junction protein in hepatocytes, in which it interacts with CD81 and occludin to block hepatitis C virus entry.

2021年7月28日 · Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for coronaviruses....

2012年12月14日 · IFN-induced transmembrane protein (IFITM) proteins constitute a family of small IFN-inducible proteins. Unlike IFIT proteins, IFITM proteins have two transmembrane domains and block the...

Interferon-induced transmembrane protein 1 (IFITM1) is a member of the IFITM family that is associated with some acute-phase cytokine-stimulated response. Recently, we demonstrated that IFITM1 was significantly upregulated in the injured spinal cords at the mRNA level.

干扰素诱导的跨膜 (IFITM) 蛋白是干扰素诱导的抗病毒蛋白家族。该家族包含五个成员，包括属于 CD225 超家族的 IFITM1、IFITM2 和 IFITM3。该基因编码的蛋白质限制多种病毒病原体进入细胞，例如甲型流感病毒、埃博拉病毒和 Sars-CoV-2。[RefSeq 提供，2021 年 11 月]