IFITM3 Forges Link Between Neuroinflammation and Aβ Production
2020年9月4日 · IFITM3 expression increased with age in mice, as did its association with γ-secretase. Knockout of IFITM3 did not affect levels of γ-secretase components but did lower …
The innate immunity protein IFITM3 modulates γ-secretase in
2020年9月4日 · Third, inhibiting IFITM3 will likely suppress Aβ and other aging-related pathological processes. Since aging upregulates IFITM3 and is the primary risk factor for AD, …
rTg(tauP301L)4510 - ALZFORUM
2014年12月22日 · Research Models rTg(tauP301L)4510. Synonyms: rTg4510, rTg(tetO-TauP301L)4510, Tau P301L
ROS-responsive nanomodulators downregulate IFITM3 expression …
ROS-responsive nanomodulators downregulate IFITM3 expression and eliminate ROS for Alzheimer's disease combination treatment. J Colloid Interface Sci. 2023 Sep;645:210-218. …
Aβ Induces Neuroinflammation and Microglial M1 Polarization via …
Aβ Induces Neuroinflammation and Microglial M1 Polarization via cGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells. Neurochem Res. 2023 Sep;48(9):2881-2894. Epub 2023 May 20 …
COVID-19 Prompts Choroid Plexus to Ring Alarm Bell - ALZFORUM
2021年6月25日 · In cases, endothelial, epithelial, and mesenchymal cells in the choroid plexus upregulated genes involved in complement and interferon pathways, including interferon …
NETWORKING FOR A CURE - ALZFORUM
2020年9月3日 · IFITM3 Forges Link Between Neuroinflammation and Aβ Production 03 Sep 2020; Stress-Associated Protein Modulates γ-Secretase to Make More Aβ 21 Mar 2020; It …
NETWORKING FOR A CURE - ALZFORUM
2020年9月8日 · IFITM3 Forges Link Between Neuroinflammation and Aβ Production 08 Sep 2020; Closing the Book on NSAIDs for Alzheimer’s Prevention 12 Apr 2019; Dementia à la …
Border Surprise: Glia Limitans Astrocytes Sit on Brain Surface
2023年11月4日 · Myocilin+ cells were rare, making up only 2 percent of all astrocytes. These cells also expressed many genes involved in immune reactivity, such as IFITM3, A2M, and C4B, …
Begone 2020: Despite COVID, Alzheimer’s Research Advanced
2021年1月4日 · IFITM3 Forges Link Between Neuroinflammation and Aβ Production 3 Sep 2020; Does Phosphorylation of Presenilin 1 Drive Microglial Migration, Aβ Clearance? 21 Aug 2020; …