Regulation of the HBV Entry Receptor NTCP and its Potential in ...
Sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes and a mediator of bile acid transport, has been identified as …
Targeting NTCP for liver disease treatment: A promising strategy
2024年9月1日 · Moreover, NTCP modulates HCV infection by enhancing BA-mediated inhibition of IFN-stimulated genes (ISGs). The regulatory function of NTCP in intrinsic hepatic immunity …
Down-regulation of cell membrane localized NTCP expression in ...
2019年6月9日 · Sodium taurocholate cotransporting polypeptide (NTCP) is the functional receptor for HBV entry. In this study, down-regulation of cell membrane localized NTCP expression in …
Hepatitis B virus rigs the cellular metabolome to avoid innate …
2021年1月4日 · Activated TBK1 and IKKε induce the activation of transcription factors, including IRF3 and nuclear factor κB, leading to the production of type I interferon (IFN) and pro …
Hepatitis B virus sensitivity to interferon-α in hepatocytes is more ...
In the cell-culture-based HBV infection models, the sensitivity of HBV to IFN-α in hepatocytes is determined more by the cell-intrinsic IFN response than by viral genotype, and improvement of …
Epigenetic reprogramming promotes the antiviral action of
2021年6月2日 · Herein, we showed that an epigenetic regimen with non-cytotoxic doses of the demethylating compound 5-azacytidine restored the anti-HBV action of IFNα in epigenetically …
Hepatitis D virus replication is sensed by MDA5 and induces IFN …
2018年7月1日 · Our study shows that (i) HDV replication, in contrast to HBV replication, 32 activates IFN-β and IFN-λ in NTCP-expressing HepG2 NTCP and HepaRG NTCP cell lines …
Hepatology：干扰素-α对不同基因型乙肝病毒的作用研究！-MedS…
干扰素-α（IFN-α）用于治疗慢性HBV感染，但是，只有20-40％的患者反应良好。 临床观察表明，HBV基因型与IFN治疗的反应相关，然而，其在HBV感染肝细胞中对IFN的病毒反应性的作 …
Infection courses, virological features and IFN-α responses of HBV ...
Infection of PXB and HepG2-NTCP cells by HBVcc genotypes. To examine the infectivity of virus produced by these stable cell clones, we first concentrated and purified the HBVcc with …
丁型肝炎病毒诱导的干扰素反应和施用的干扰素控制细胞分裂介导 …
用 ifn-α/-λ1 处理可抑制 hdv 在分裂的 huh7 ntcp细胞中的传播，但对静息细胞中的 hdv 复制表现出边际效应。 用 JAK1/2 抑制剂鲁索替尼阻断 HDV 诱导的 IFN 反应或敲低 MDA5 可增强 HDV …
- 某些结果已被删除