Mechanisms of NF-κB p65 and strategies for therapeutic …
The increased nuclear IκBα in turn removes the NF-κB p65 complex from the DNA terminating its transcriptional activity. 19, 22 As nuclear p65:DNA interaction exhibits fast dissociation …
经典信号通路总结——NF-κB信号通路 - 知乎 - 知乎专栏
NF-κB蛋白通常会由p65和p50形成同源/异源二聚体，在胞质中因与抑制蛋白IkB结合形成了三聚体复合物而处于失活状态。 当上游信号因子TNF结合到细胞膜表面受体后，受体构象改变并将 …
Pathway干货 | NF-Kb 信号通路简介 - 知乎 - 知乎专栏
包括p65的磷酸化调节和p65的乙酰化调节、p53对转录的竞争性调节，gsk3β对转录的间接调节；nf-κb转录调节中的常见的激酶：pka（蛋白激酶a），msk1和msk2（分裂素和压力激活激酶 …
The IκB kinase complex: master regulator of NF-κB signaling
IκB degradation reveals a nuclear localization sequence on NF-κB proteins (e.g., a p50-p65 heterodimer) allowing them to migrate to the nucleus, bind to specific κB-sites and regulate …
靶点解惑Plus | NF-κB p65, p62和 Nrf2信号通路详解，剖析氧化应 …
NF-κB p65 是NF-κB家族成员之一，NF-κB是一种多效性转录因子，几乎存在于所有细胞类型中，并参与许多生物学过程，例如炎症、免疫、分化、细胞生长、肿瘤发生和凋亡。 NF-κB受翻 …
NF-KB p65的问题：总p65不变， 胞浆pp65增加，核内pp65增加这 …
NF-KB p65的问题：总p65不变， 胞浆pp65增加，核内pp65增加这该怎么解释？ IκBα抑制剂（BAY11-7082, 30 mM）效果很明显。 有人做的胞浆pp65是减少的，而我的增加，我是这么解 …
【实验求助】IKB磷酸化和NF-KB 信号的激活 - 丁香园论坛
NF kappa B 信号通路的激活一般分为两种途径：1. 经典的信号通路：IKK---IK--p65。 一般为IKK 磷酸化，引起IK 磷酸化，再引起p65（即NF kappa B分子）磷酸化，释放p65入核，从而调节 …
Transcription factor NF-KB (p50/p65) is generally localized to the cytoplasm by its inhibitor IKB. Overproduced IKB, free from NF-KB, israpidly degraded. Overexpression of p65 increases …
The IκB kinase complex in NF-κB regulation and beyond - PMC
IKK activation results in phosphorylation of IκB and p65. IκB phosphorylation leads to its ubiquitin-mediated proteasomal degradation, enabling NF-κB dimers translocation to the nucleus, …
DNA binding and IκB inhibition of the cloned p65 subunit of …
1991年3月8日 · DNA binding by truncated p65 is inhibited by IκB, thus mapping the IκB interaction domain to the rel -homologous region and suggesting that IκB exerts its inhibitory …