IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene.

IKK（inhibitor of kappa B kinase [2], kappa B 抑制因子激酶）参与胞内多种细胞信号转导途径，包括由 细胞因子 引起的 细胞凋亡,其中最为人熟知的是可以通过磷酸化 细胞质基质 中与 NF-κB [1] 【p65-p50二元复合体蛋白】结合的 IκB α蛋白，使其得以被E3 泛素连接酶 特异性识别 并添加降解型K48型多聚泛素链，随后被26S 蛋白酶体 特异性识别并降解，进而释放出异二聚体蛋白NF-κB，后者可通过 细胞核 核膜 上的 核孔 通道入核并随后 特异性结合 免疫球蛋白 κ 轻链 基因的上游 …

NF-κB （Nuclear Factor kappa-light-chain-enhancer of activated B cells）通路是一种在细胞信号传递中极为重要的途径，它在 调控免疫反应 、 炎症反应 、 细胞生长与死亡 等多种生理过程中起着关键作用。 这一通路能够响应多种刺激，包括 促炎细胞因子、自由基、紫外线辐射、细菌和病毒感染等，进而调控多种基因的表达。 NF-κB 是一组蛋白质复合体的统称，主要包含 RelA (p65)、 RelB 、 c-Rel 、 p50 / p105 (NF-κB1) 和 p52 / p100 (NF-κB2) 等亚单位。 在未被激活状态 …

2008年4月1日 · IKKβ/IKBKB (IκB kinase beta), also designated as IKK2, was named after its function of phosphorylating IκB molecules, the inhibitors of NF-κB transcription factors.

1997年10月31日 · Two components of the IKK signalsome, IKK-1 and IKK-2, were identified as closely related protein serine kinases containing leucine zipper and helix-loop-helix protein interaction motifs. Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-kappaB-dependent reporter activity, consistent with a critical role for ...

2002年4月19日 · IKK-1 and IKK-2 are two direct IkappaB kinases. Two recently identified novel IKKs are IKK-i and TBK-1. We have cloned, expressed, and purified to homogeneity recombinant human (rh)IKK-i and rhTBK-1 and compared their enzymatic properties with those of rhIKK-2. We show that rhIKK-i and rhTBK-1 are enzymatically similar to each other.

Inhibitory kappa B kinase beta (IKKβ), known as IKK2, is a key regulatory kinase responsible for the activation of NF-κB through its phosphorylation at Ser177 and Ser181 to promote the phosphorylation of inhibitors of kappa B (IκBs), triggering their ubiquitination and degradation to active the nuclear factor kappa-B (NF-κB) cascade.

2018年5月21日 · Inhibitor kappa B kinase 2 (IKK2) plays an essential role in the activation of nuclear factor kappa B (NF-kB). Recently, it has been suggested that IKK2 acts as a myosin...

IKKbeta/IKBKB (IkappaB kinase beta), also designated as IKK2, was named after its function of phosphorylating IkappaB molecules, the inhibitors of NF-kappaB transcription factors.

2007年1月1日 · Inhibitors of IKK-2, which inhibit signaling in the NF-κB pathway (initiated by TNF-a binding to its receptor), represent potential new drug candidates, as shown by the biology/biochemistry of the target and the in vivo activity of inhibitors in a variety of disease-relevant models.