The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta and the common gamma chain .

2024年12月25日 · IL2RA (Interleukin 2 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL2RA include Immunodeficiency 41 With Lymphoproliferation And Autoimmunity and Type 1 Diabetes Mellitus 10. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and TGF-Beta Pathway.

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a …

Elevated levels of soluble interleukin-2 receptor α-chain (IL-2Ra/CD25) are detected in the serum of patients with a broad spectrum of conditions associated with T- or B-cell immune activation, including infections, inflammation, lymphomas, and autoimmune disease. 1 For some of these conditions, measurement of IL-2Ra/CD25 levels is used in ...

2018年8月8日 · This study identifies a STAT5-based super-enhancer as the key regulatory element mediating IL-2-induced gene regulation of Il2ra and dissects the functional elements of the super-enhancer.

IL-2 and its receptor have key roles in key functions of the immune system, tolerance and immunity, primarily via their direct effects on T cells.

2023年8月7日 · Here we show that both wild-type (IL-2 wt) and IL-2Rβγ-attenuated (IL-2 α-bias) agonists that preserve IL-2Rα (CD25) activities can effectively expand tumor-specific CD8 + T cells (TSTs) and...

The IL2RA gene is composed of eight exons and encodes the α chain of the IL-2 receptor complex (also known as CD25). IL2RA is central to immune regulation as an important modulator of immunity. IL2RA expression on regulatory T cells is essential for their function in suppressing T cell immune responses and autoimmune disease [58–60] .

2024年10月15日 · Emerging IL-2 therapies with reduced IL-2 receptor alpha (IL-2Rα) binding aim to mitigate toxicity and regulatory T cell (Treg) expansion but have had limited clinical success. Here, we show that IL-2Rα engagement is critical for …

2025年1月4日 · Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and …