2018年8月8日 · IL-2 has been shown to induce STAT5-mediated IL-4Rα expression, priming cells for T H 2 differentiation, as well as to induce epigenetic changes at the Il4 locus, promoting T …

il-2是肿瘤浸润淋巴细胞的关键生长因子，该细胞可与il-2在体外一起扩增，用于治疗性回输给患者。通过平衡il-2的量或通过使用新的il-2类似物与il-2特异性抗体组合，可以平衡t细胞反应，控 …

Interleukin-2 (IL-2), a 15.5-kDa variably glycosylated globular protein, was first described as T cell growth factor (TCGF), a potent mitogen and growth regulator of T cells in vitro (1 – 6).

白细胞介素-2 (il-2)又称t细胞生长因子，tcgf。 主要由T细胞产生。 是在淋巴细胞增殖分化过程中重要的细胞生长因子，生理作用有刺激T细胞生长、诱导细胞毒作用和对B细胞的生长及分化均 …

2024年3月12日 · Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) …

2012年2月17日 · IL-2 signals act via signal transducer and activator of transcription 5 (STAT5) and influence the differentiation of T helper (T H) cell subsets (including T H 1, T H 2 and T H …

2022年3月8日 · A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia. Science Translational Medicine, 2022, …

These basic mechanistic studies have led to the therapeutic ability to manipulate the action of IL-2 on regulatory T (T reg) cells for the treatment of autoimmune disease and on CD8 + T cells for …

Interleukin-2 (IL-2) is a pleiotropic cytokine that drives T-cell growth, augments NK cytolytic activity, induces the differentiation of regulatory T cells, and mediates activation-induced cell …

Interleukin-2 (IL-2) is a pleiotropic cytokine that drives T-cell growth, augments NK cytolytic activity, induces the differentiation of regulatory T cells, and mediates activation-induced cell …