Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 …
2018年9月5日 · In contrast to IL-6 classic signaling, IL-6 trans-signaling induces the release of the pro-inflammatory chemokine Monocyte Chemoattractant Protein-1 (MCP-1) from human …
Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 …
2008年4月1日 · Interleukin-6 (IL6) is a growth and survival factor in human prostate cancer (PCa) cells with aggressive phenotypes and has been implicated in the progression of hormone …
Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 …
2018年9月5日 · Furthermore, we demonstrate that MCP-1 induction by IL-6 trans-signaling requires simultaneous activation of the JAK/STAT3 and PI3K/AKT pathways. Collectively, our …
Interleukin (IL) 1β Induction of IL-6 Is Mediated by a Novel ...
Here we describe a novel role for the phosphatidylinositol 3-kinase/AKT pathway in mediating induction of interleukin-6 (IL-6) in response to IL-1. Pharmacological inhibition of …
白介素IL-6信号转导及其通路研究概述 - 知乎 - 知乎专栏
IL-6结合受体有两种，一种是特异性受体 IL-6R （80kDa I型跨膜蛋白），另一种是gp130，是IL-6家族细胞因子的所有成员的常见受体亚单位。gp130可以在所有细胞表达，但IL-6R的表达受 …
IL-6 通路 | Cell Signaling Technology
IL-6 信号转导异常参与了自身免疫疾病、炎症和部分癌症（如前列腺癌和多发性骨髓瘤）的发病机理。 目前 Jak 抑制剂在多发性骨髓瘤模型中进行测试。 Stat3 可充当一种致癌基因，并在许 …
PI3K-Akt信号通路详解：通路激活+通路组成+通路串联+通路检 …
PI3K-Akt信号通路是细胞中一个关键的信号传导网络，它可被多种细胞刺激或毒性损伤所激活，并在调控转录、翻译、增殖、生长和存活等基本细胞功能中扮演重要角色。 当生长因子与细胞 …
Advances in Interleukin-6 Family Cytokines and the Role in …
It is reported that IL-6 has a protective effect on neuronal cells through the JAK/STAT3, MAPK/ERK and PI3K/AKT signaling pathways. 29 In addition, IL-6 increased autophagy in …
Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6 …
2019年8月13日 · Results: Studies of three IL-6-blockade refractory iMCD cases revealed increased CD8+ T cell activation, VEGF-A, and PI3K/Akt/mTOR pathway activity. …
Experiment-based computational model predicts that IL-6
2023年9月21日 · Our model quantitatively characterized the effects of IL-6 classic and trans-signaling in activating the signal transducer and activator of transcription 3 (STAT3), …