IL-6，至关重要的多功能细胞因子 - 知乎 - 知乎专栏
IL-6是一种具有多效活性的细胞因子，可以促进多种细胞的增殖和分化，也可以加速肝细胞 急性期蛋白 的合成，还可以抑制M1髓性白血病细胞系的生长，促进其成熟和分化，抑制黑素瘤、乳 …
炎性多因子检测之白介素细胞6(IL-6) - 知乎 - 知乎专栏
IL-6作为抗炎性肌动蛋白的作用是通过其对 TNF-α 和 IL-1 的抑制作用以及 IL-1ra 和 IL-10 的激活而介导的。 早期证据表明，在更广泛的冠状病毒大流行的背景下，IL-6可以用作严重COVID-19 …
Human interleukin-6 acts as a co-factor for the up-regulation of C3 ...
We investigated the role of human interleukin-6 (IL-6) in the regulation of the third component of complement (C3) biosynthesis by cultured rat liver epithelial cells. A natural human IL-6 (nh IL …
The Role of Interleukin-6 Family Members in Cardiovascular Diseases
IL-6 plays a key role in the development of autoimmune heart disease, possibly by upregulating complement C3. IL-6 KO mice with autoimmune myocarditis showed a reduction in …
Interleukin 6 stimulates synthesis of complement proteins
Here we report that in fibroblasts, IL 6 induces increases in the rate of synthesis of factor B and C3, activator proteins of the alternative pathway of complement activation. The increases in …
细胞因子风暴标志物—白介素6（IL-6） - 知乎专栏
白细胞介素-6 (IL-6)是一种重要的促炎细胞因子，在感染或组织损伤过程中释放，促进先天和获得性免疫反应。 IL-6由天然免疫细胞，如巨噬细胞，在遇到损伤相关分子模式 (DAMP)或病原体 …
Recombinant rat IL-1β and IL-6 synergistically enhance C3 mRNA levels ...
2005年4月21日 · IL-1β and IL-6 demonstrated synergy with respect to the quantity and rate of increase of C3 mRNA measured and the magnitude of C3 protein secretion. Previous reports …
The IL-6/STAT3 pathway regulates adhesion molecules and cytoskeleton …
2018年4月1日 · C3 significantly counteracted the effects of IL-6 in reducing p-eNOS expression and increasing the expression of MMP-9, ICAM-1 and VCAM-1 (Fig. 3 B). In addition, …
Recombinant rat IL-1beta and IL-6 synergistically enhance C3 …
2005年4月21日 · IL-1beta and IL-6 demonstrated synergy with respect to the quantity and rate of increase of C3 mRNA measured and the magnitude of C3 protein secretion. Previous reports …
Complement C3 overexpression activates JAK2/STAT3 pathway …
2020年1月13日 · We employed CR1 to block exogenous activation of C3 and detected a weakened expression of p-STAT3 and IL-6 compared with AG490-treated cancer cells (Fig. …