
Interleukin-6 in Rheumatoid Arthritis - PubMed
2020年7月23日 · The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory …
Interleukin-6 in Rheumatoid Arthritis - PMC - PubMed Central …
An increase in serum IL-6 and IL-21 levels is associated with markers of B cell activation, and IL-6 is associated with radiographic progression in patients with RA . Based on studies …
High levels of interleukin-6 in patients with rheumatoid arthritis …
2020年10月20日 · Increased levels of cytokines, including interleukin-6 (IL-6), reflect inflammation and have been shown to be predictive of therapeutic responses, fatigue, pain, and depression …
The Role of Interleukin 6 in the Pathophysiology of Rheumatoid ...
Interleukin 6 (IL-6) is a pleiotropic cytokine with a pivotal role in the pathophysiology of rheumatoid arthritis (RA). It is found in abundance in the synovial fluid and serum of patients with RA and …
Translating IL-6 biology into effective treatments - Nature
2020年4月23日 · Targeting of the IL-6 pathway has led to innovative therapeutic approaches for various rheumatic diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, adult …
The role and therapeutic targeting of IL-6 in rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune chronic disease with joint and systemic inflammation and it has been found that interleukin-6 (IL-6) plays a key role in RA. Indeed, various clinical …
Role of Interleukin 6 Inhibitors in the Management of Rheumatoid ...
Interleukin 6 (IL-6) plays a prominent role in the pathophysiology of RA and is an important therapeutic target for RA. Tocilizumab and sarilumab are approved IL-6 inhibitors, which have …
Understanding the Role of Interleukin-6 (IL-6) in the Joint
2020年7月30日 · This narrative review describes the role of IL-6 in the pathogenesis of RA, its comorbidities, and extra-articular systemic manifestations, and examines the effects of the IL-6 …
What have we learnt from the inhibition of IL-6 in RA and what …
2024年10月21日 · This review explores the role of IL-6 in RA pathogenesis, its potential as a treatment target and the significance of personalised medicine in RA management. IL-6 has a …
Targeting IL-6 or IL-6 Receptor in Rheumatoid Arthritis ... - Springer
2023年11月21日 · Sirukumab and clazakizumab bind to site 1 and interfere with the binding of IL-6 to the IL-6 receptor (IL-6R)-α in the IL-6–IL-6R–gp130 trimolecular complex and prevents …