Inosine 5′-monophosphate dehydrogenase (IMPDH) is a purine biosynthetic enzyme that catalyzes the nicotinamide adenine dinucleotide (NAD +)-dependent oxidation of inosine …

IMP可被次黄嘌呤核苷酸脱氢酶（IMPDH）氧化生成黄嘌呤，再由鸟苷酸合成酶（GMPS）催化，接受谷氨酰胺的氨基，生成GMP。 AMP与GMP的合成是互相影响的。 ADSS需要GTP， …

2016年11月3日 · 次黄嘌呤单核苷酸脱氢酶（impdh）是一种鸟嘌呤从头合成途径的限速酶，在细胞增殖过程中发挥着重要作用。目前临床常用的作用于impdh的药物为impdh抑制剂，主要应 …

IMPDH is a purine biosynthetic enzyme that catalyzes the conversion of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP). The abnormal expression of …

IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. IMP is the product of de novo purine nucleotide biosynthesis and the …

2012年7月13日 · Inosine monophosphate dehydrogenase (IMPDH) controls the guanine nucleotide pool and, thereby, cell proliferation. We found that Drosophila IMPDH is also a DNA …

Inosine-5'-monophosphate dehydrogenase (IMPDH) is an enzyme involved in the de novo biosynthesis of guanine nucleotides. To date human IMPDH inhibitors have been approved for …

1996年6月14日 · The structure of inosine-5′-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH …

Inosine-5′-monophosphate dehydrogenase (IMPDH) is a highly conserved enzyme in purine metabolism that is tightly regulated on multiple levels. IMPDH has a critical role in purine …

肌苷单磷酸脱氢酶（impdh）是嘌呤核苷酸从头合成的关键酶，被视为在抗病毒，抗菌和抗癌治疗领域中寻找药物的重要靶标。这篇综述着重于impdh的药物化学，药物发现和化学生物学。提 …