The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na+). It is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ, [2] These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D.

The ENaC 2 has evolved as a channel that is thought to reside primarily in an active state, facilitating the bulk movement of Na + out of renal tubular or airway lumens. The regulated insertion and retrieval of channels at the plasma membrane have important roles in modulating ENaC-dependent Na + transport (1).

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2023年7月24日 · The ENaC causes endothelium-dependent relaxation impairment in mice aorta through the ROS/COX-2-mediated SGK-1/Nedd4-2 signaling pathway; blocking the ENaC facilitates attenuation of hyperhomocysteinemia-induced cardiovascular system disease (79).

ENAC es firmante de los Acuerdos de Reconocimiento Mutuo establecidos en el seno de la European co-operation for Accreditation (EA) y de las organizaciones internacionales de organismos de acreditación, ILAC e IAF (www.enac.es)

The epithelial sodium channel (ENaC) is the rate-limiting step for sodium reabsorption across tight epithelia. Cyclic-AMP (cAMP) stimulation promotes ENaC trafficking to the apical surface to increase channel number and transcellular Na+ transport. ...

2015年12月15日 · Amiloride-sensitive epithelial sodium (Na +) channels (ENaCs) play a crucial role in Na + transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ.

2018年8月28日 · Here, we report that the epithelial sodium channel (EN aC) is upregulated and activated in the uterus at labor in mice. Mechanical activation of EN aC results in phosphorylation of CREB and upregulation of pro‐inflammatory cytokines as …

2018年1月1日 · ENaC is generally located at the apical surface of polarized epithelial cells in tight or high-resistance epithelia in the organs including kidney, lung, sweat glands, salivary glands, skin, placenta, colon, etc. ENaC drives the active Na + transport across the cell membrane, consequently regulates the flow and volume of the extracellular fluid ...

CES trabaja para conseguir que sus proyectos sean calificados como I+D+i por todos los organismos pertinentes, desde certificados ENAC hasta conseguir los Informes Motivados del Ministerio de Economía y Competitividad (MINECO) que certifican que los proyectos son considerados como Investigación, desarrollo e innovación.