2022年6月1日 · SMARCB1 (SWI / SNF related, matrix associated, actin dependent regulator of chromatin subfamily B member 1), INI1 (integrase interactor 1), BAF47, hSNF5

We will review the clinicopathologic features of these tumor types and emphasize the clinical utility of INI1 immunohistochemistry in differential diagnosis. Significant progress has been made in understanding the molecular genetic alterations involved in sarcomagenesis.

SWI/SNF -related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene. [5][6][7] The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively.

2022年6月14日 · smarcb1/ini1是抑癌基因，位于染色体22q11.23，编码蛋白认为是swi/snf染色质重塑复合物的一种核心亚基，在所有正常细胞的细胞核中广泛表达，是细胞分化期间转录程序转变所必需的。

INI1（SMARCB1）蛋白是染色体重塑相关多聚体蛋白SWI/SNF的一个亚单位，SWI/SNF复合体缺失的未分化癌对传统化疗药物不敏感、预后差，但组蛋白甲基转移酶抑制剂治疗可能有效，而本例极易与低分化鳞癌、腺鳞癌混淆，故将INI1（SMARCB1）缺失的肿瘤识别出来十分必要。 引用本文: 周也涵, 覃胜, 颜佳欣, 等. INI1（SMARCB1）缺失性肺癌1例 [J] . 中华病理学杂志, 2022, 51 (9) : 902-904. DOI: 10.3760/cma.j.cn112151-20220207-00076. 版权归中华医学会所有。 未经授 …

SMARCB1/INI1 is one of the core subunit proteins of the ATP‐dependent SWI/SNF chromatin remodeling complex, and is identified as a potent and bona fide tumor suppressor. Interactions have been demonstrated between SMARCB1/INI1 and key proteins in ...

2020年6月30日 · SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1), also known as integrase interactor 1 (INI1), is a crucial component of a chromatin-remodeling protein complex. SMARCB1/INI1 was first identified in yeast in the late 1980s 1. By 1994, its human homologue was isolated in fibroblast cells 2, 3.

2023年11月10日 · SMARCB1/INI1缺陷胰腺未分化横纹肌样癌是一种非常具有侵袭性的肿瘤，文献中很少报道。 肿瘤有主要的横纹肌细胞成分和不同的生长模式已被报道。 一名59岁女性，表现为弥漫性腹痛，严重程度增加，并伴有体重减轻、恶心和呕吐。 影像学显示胰腺头部肿块。 细针穿刺显示非典型上皮样细胞与假乳头状生长模式提示实性假乳头状肿瘤。 切除的肿瘤显示单调的上皮样细胞和局灶梭形细胞，具有假乳头状结构，横纹肌样特征，SMARCB1蛋白表达缺失，具有 …

整合酶相互作用因子1（integrase interactor 1，INI-1）是染色质重塑复合物SWI/SNF的核心亚基，位于染色体22q11.2位置，是基因表达和细胞分化的重要调节因子，于20世纪90年代首次在酵母中被发现 [1] ，随后其人类同源物在成纤维细胞中被分离出来，核INI1基因作为肿瘤 ...

SMARCB1 (INI1) is a core subunit of the SWItch/sucrose non-fermentable (SWI/SNF) complex mapped to chromosomal region 22q11.23. Though many SWI/SNF protein subunits are interchangeable, SMARCB1 (also known as INI-1, INI1, or integrase interactor 1, BAF47, SNF5, CSS3, Snr1, MRD15, RDT, RTPS1, Sfh1p, hSNFS, SNF5L1, SWNTS1, and PPP1R144) is an ...