
CXCL10/IP-10 in infectious diseases pathogenesis and potential ...
2020年6月11日 · CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 expression levels have been associated with inflammatory diseases including infectious diseases, immune dysfunction and tumor development. CXCL10 is also recognized as a biomarker that predicts severity of various diseases.
CXCL10 - Wikipedia
C-X-C motif chemokine ligand 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene. [5][6] C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.
CXCL10/IP-10 in infectious diseases pathogenesis and potential ...
CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 expression levels have been associated with inflammatory diseases including infectious diseases, immune dysfunction and tumor development. CXCL10 is also recognized as a biomarker that predicts severity of various diseases.
IFN-γ-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a …
2002年4月1日 · IFN-γ-inducible protein 10 (IP-10, CXCL10), a chemokine secreted from cells stimulated with type I and II IFNs and LPS, is a chemoattractant for activated T cells. Expression of IP-10 is seen in many Th1-type inflammatory diseases, where it is thought to play an important role in recruiting activated T cells into sites of tissue inflammation.
IP-10 and MCP-1 as biomarkers associated with disease severity ... - PubMed
2020年10月29日 · Interferon gamma inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1α) are cytokines related to thrombosis. Therefore, this study focused on these three indicators in COVID-19, with the hope to find biomarkers that are associated with patients' outcome.
Importance of IP-10 as a biomarker of host immune response: …
2023年1月1日 · Interferon Gamma-induced Protein 10 (IP-10) plays a vital role as a biomarker in a wide variety of diseases. IP-10 is a chemokine secreted in response to IFN-γ and plays a …
Plasma IP-10 and MCP-3 levels are highly associated with disease ...
In this study, we report biomarkers that are highly associated with disease severity and progression of COVID-19. These findings add to our understanding of the immunopathologic mechanisms of severe acute respiratory syndrome coronavirus 2 infection, and provide potential therapeutic targets and strategies.
Serum IFN-γ-induced protein 10 (IP-10) as a biomarker for ... - PubMed
Results: Serum IP-10 concentrations from 225 ARI episodes correlated with ARI global severity (rho 0.28 [95% CI: 0.15-0.39]; p<0.001). IP-10 concentrations were higher with an ARI in which a viral pathogen was detected compared to no viral pathogen detected (median 366pg/ml [IQR: 227-486] vs 163pg/ml [IQR: 127-295], p<0.0001).
Frontiers | Screening and identification of host signaling pathways …
2025年1月26日 · To identify the key host signaling pathways responsible for producing pro-inflammatory cytokines, we utilized a U937 cell model that secretes IP-10, IL-8, and MCP-1 in response to influenza infection.
IP-10 and MCP-1 as biomarkers associated with disease severity …
2020年10月29日 · Interferon gamma inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1α) are cytokines related to thrombosis. Therefore, this study focused on these three indicators in COVID-19, with the hope to find biomarkers that are associated with patients’ outcome.