Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP 2), a phospholipid that is located in the plasma membrane, by phospholipase C …

‌IP3（inositol triphosphate， 三磷酸肌醇）是一种肌醇磷酸信号分子，是参与 G蛋白 耦联受体介导的信号转导的第二信使。 在 磷脂酰肌醇 途径中，胞外 信号分子 与其相应的G蛋白偶联受体结合后，激活膜上的Gq蛋白（一种作用于磷脂酰 肌醇 系统的G蛋白），然后由Gq蛋白激活 磷酸酯酶 Cβ （phospholipase Cβ， PLC）， 将膜上的4，5-二 磷酸 脂酰肌醇（phosphatidylinositol biphosphate， PIP2）分解为两个细胞内的 第二信使： DAG和IP₃，最后通过激活 蛋白激酶C …

Three IP 3 R isoforms are responsible for the generation of intracellular Ca 2+ signals that may spread across the entire cell or occur locally in so-called microdomains. Because of their ubiquitous expression, these channels are involved in the regulation of a plethora of cellular processes, including cell survival and cell death.

Inositol 1,4,5-trisphosphate receptors (IP 3 Rs), by releasing Ca 2+ from the endoplasmic reticulum (ER) of animal cells, allow Ca 2+ to be redistributed from the ER to the cytosol or other organelles, and they initiate store-operated Ca 2+ entry (SOCE).

6-(ortho-nitroveratryl)-caged IP3 MeSH Supplementary Concept Data 2025. Details; Concepts

Here, we review the role of IP3 as an intracellular and intercellular cell death messenger, focusing on the endoplasmic reticulum-mitochondrial synapse, followed by a discussion of plausible elements that can convert IP3 from a physiological molecule to a killer substance.

Type 3 inositol 1,4,5-triphosphate receptor (IP3R3) is an a tetrameric channel that can mediate the release of Ca 2+ from the endoplasmic reticulum (ER) in response to extracellular stimuli. The gating of IP3R3 is regulated not only by ligands but also by other interacting proteins.

2010年1月1日 · Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) are members of the intracellular Ca 2+ release channel family that are essential to a wide array of cellular processes, relying on transient changes in cytoplasmic (CY) Ca 2+ concentration. Understanding how these channels function is an important frontier of structural biology.

2017年10月1日 · Full-length tetrameric structure of IP 3 R1 has been solved at 4.7 Å resolution. The overall structure was validated by multiple methods. The central four-helix bundle provides a supporting scaffold for the cytosolic assembly. Direct structural coupling between the C-terminal and IP 3 -binding domains is revealed.

2023年7月1日 · Inositol 1,4,5-trisphosphate (IP3)-evoked cytosolic Ca 2+ signals through IP 3 receptors (IP 3Rs) regulate vastly diverse and sometimes opposing cellular processes, such as cell division or cell death. High-resolution cryo-EM structures of tetrameric IP 3 R have recently provided a framework for understanding their function.