Isoniazid preventive treatment (IPT) for 6 months was the mainstay of TPT until recently, for both adults and children, HIV-positive and HIV-negative, and in high and low TB incidence …

2025年2月22日 · The PHOENIx-MDR TB [NCT03568383] trial aims to compare the safety and efficacy of a six-month regimen of delamanid (DLM) versus a six-month regimen of isoniazid in …

TPTs for an infection with M. tuberculosis strains presumed to be drug-susceptible can be broadly categorized into two types: monotherapy with isoniazid for at least 6 months (IPT) and …

TB preventive treatment (TPT) can reduce the risk of individuals developing TB disease and is a powerful and necessary tool to end the global TB epidemic. TPT is, in short, treatment for TB …

2024年12月28日 · People infected with tuberculosis (TB) are at high risk of progressing to TB disease. Tests can identify people infected with TB who may benefit from preventive …

2025年2月25日 · Preventing MDR/RR-TB remains a significant challenge towards global TB elimination. While the recent WHO recommendation for 6Lfx is a promising step, expanding …

We find that the optimal epidemiological settings for the programmatic use of IPT against LTBI occur at surprisingly high levels of TB incidence. The NNT initially falls as TB incidence …

TPT for contacts of people with TB strains resistant to both isoniazid and rifampicin (multidrug-resistant TB or MDR-TB) may still be possible but different medicines are used. MDR-TB is a …

2024年3月24日 · Multidrug-resistant or rifampicin-resistant TB (MDR/RR-TB; resistance to rifampicin and isoniazid, or rifampicin alone) is a burgeoning public health challenge in several …

Isoniazid preventive therapy (IPT) is the provision of the drug isoniazid to people at high risk of developing active tuberculosis (TB). Those with HIV are 20 to 37 times more likely to develop …