Interleukin-1 receptor-associated kinase 1 (IRAK-1) is an enzyme in humans encoded by the IRAK1 gene. [5] [6] IRAK-1 plays an important role in the regulation of the expression of inflammatory genes by immune cells, such as monocytes and macrophages, which in turn help the immune system in eliminating bacteria, viruses, and other pathogens.

2024年12月25日 · IRAK1 (Interleukin 1 Receptor Associated Kinase 1) is a Protein Coding gene. Diseases associated with IRAK1 include Pediatric Systemic Lupus Erythematosus and Mumps. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Bacterial infections in …

Interleukin-1 receptor activated kinases (IRAKs) are key mediators in the signaling pathways of TLRs/IL-1Rs. By means of their kinase and adaptor functions, IRAKs initiate a cascade of signaling events eventually leading to induction of inflammatory target gene expression.

IRAK1 is a threonine/serine kinase. Unlike IRAK4, IRAK1 is not a core constituent of the Myddosome but transiently interacts with IRAK4 upon Myddosome assembly. Unlike IRAK4, IRAK1 exists primarily in an inactive conformation at the basal state and requires upstream stimulation for rapid activation .

2024年5月9日 · Interleukin receptor-associated kinase (IRAK) proteins are pivotal in interleukin-1 and Toll-like receptor-mediated signaling pathways. They play essential roles in innate immunity and inflammation. This review analyzes and discusses the physiological functions of IRAK1 and its associated diseases.

2014年10月7日 · Interleukin-1 receptor-associated kinase (IRAK) family members are mediators of TLR/IL1R superfamily signalling, and mounting evidence implicates these kinases as viable cancer...

IRAK1 Is a Critical Mediator of Inflammation-Induced Preterm Birth. A new insight into thymosin beta4, a promising therapeutic approach for neurodegenerative disorders. Polymorphisms of IRAK1 Gene on X Chromosome Is Associated with Hashimoto Thyroiditis in Korean Children.

2008年2月1日 · Interleukin-1 receptor activated kinases (IRAKs) are key mediators in the signaling pathways of TLRs/IL-1Rs. By means of their kinase and adaptor functions, IRAKs initiate a cascade of signaling events eventually leading to …

该基因编码白细胞介素 1 受体相关激酶 1，这是两种推定的丝氨酸/苏氨酸激酶之一，在刺激后与白细胞介素 1 受体 (IL1R) 相关。 该基因部分负责 IL1 诱导的转录因子 NF-kappa B 的上调。 已 …

IRAK1 is a class of serine-threonine protein kinases related to IL-1R and TLR signaling that plays a major role in initiating the innate immune response against foreign pathogens. From: European Journal of Medicinal Chemistry, 2023. You might find these chapters and articles relevant to this topic. Sridevi Gottipati, ...