The C/EBP Homologous Protein (CHOP) Transcription Factor …
ER-induced apoptosis occurs via three primary pathways, including the IRE1/ASK1/JNK pathway, the caspase-12 kinase pathway, and the C/EBP homologous protein (CHOP)/GADD153 pathway (11, 12). The IRE1/ASK1/JNK pathway is important for apoptosis in the ER and has been found active during many diseases, such as osteoporosis, urothelial carcinoma ...
【细胞凋亡原创系列二】细胞凋亡通路 - 知乎 - 知乎专栏
UPR条件下，IRE1-JNK帮助细胞自救，是重要的信号通路。 一方面，IRE1活性运动可切割XBP-1 mRNA，使它成为有效的转录激活因子，诱导蛋白基因转录，编码ER分子伴侣，缓解ER压力。
New insights into the roles of CHOP-induced apoptosis in ER stress
2014年8月1日 · Although both the IRE-1 and ATF6 pathways can up-regulate CHOP, the PERK pathway predominates through selective up-regulation of translation of ATF4, which subsequently induces transcription of CHOP and other genes involved in amino acid metabolism and transport, and oxidation–reduction reactions.
详解内质网应激/未折叠蛋白反应三条信号通路 - 简书
2020年8月8日 · 内质网应激过于严重ATF4会启动chop的转录，chop启动促凋亡程序促进细胞凋亡。 3. ATF6通路： ATF6与GRP78/BiP分离后会从ER膜上掉下来，跑到高尔基体被蛋白酶裂解，生成转录因子ATF6p50。 进入细胞核中通过启动一系列基因转录从多个层次缓解内质网应激。 作者：SQW， 免疫学在读硕士生 ，专注肿瘤免疫学/T细胞/细胞因子文献分享与科普~ 内质网应激： 在细胞当中，内质网（ER）负责将多肽链正确折叠和加工成有功能的蛋白质。 一些外源性或内 …
Novel mechanism of enhancing IRE1α-XBP1 signalling via the …
2016年4月7日 · Mammalian inositol-requiring enzyme 1α (IRE1α) is the most conserved of all endoplasmic reticulum (ER) stress sensors, which includes activating transcription factor (ATF)...
IRE1 signaling increases PERK expression during chronic ER stress
2024年4月18日 · In this study, we demonstrate cross talk between the IRE1 and PERK branches of the UPR, wherein IRE1 via XBP1s signaling helps to sustain PERK expression during prolonged ER stress. Our...
Roles of CHOP/GADD153 in endoplasmic reticulum stress
2003年12月19日 · These results suggest that the PERK/eIF2α signaling pathway plays an essential role in the induction of CHOP in ER stress, and is dominant over that of the ATF6 and Ire1/XBP-1 signaling...
刘勇课题组揭示未折叠蛋白响应分子IRE1α与应激颗粒共聚集的动 …
2024年5月8日，武汉大学生命科学学院刘勇教授课题组在Nature Cell Biology杂志上在线发表了题为“Mammalian IRE1α dynamically and functionally coalesces with stress granules” 的研究论文，发现IRE1α能够在不同应激条件下与应激颗粒（Stress granule,...
国际期刊|IF21.3！武汉大学刘勇团队首次揭示内质网应激关键分 …
为研究细胞抗逆应激的生物学机制，武汉大学生命科学学院刘勇教授课题组于2024年5月8日在国际学术期刊《Nature Cell Biology》（IF：21.3）上发表题为“Mammalian IRE1α dynamically …
Endoplasmic Reticulum Stress: Implications in Diseases
3 天之前 · Phosphorylated IRE1 levels also rise in PD samples illustrating IRE1-XBP1 signalling to be linked to the pathology of PD . Studies have illustrated the modulation of CHOP, ATF4, and BiP levels in the substantia nigra pars compacta (SNpc) in post-mortem samples of the human brain . All these observations confirmed the connection between ER ...