
ERN1 Gene - GeneCards | ERN1 Protein | ERN1 Antibody
2024年12月25日 · Inositol-requiring enzyme 1 (IRE1) is a resident transmembrane ER protein with both kinase and endonuclease domains. Both yeast (IRE) and mammalian (IRE1alpha) homologs are involved in the degradation of misfolded proteins, as part of the unfolded protein response (UPR).
ERN2 Gene - GeneCards | ERN2 Protein | ERN2 Antibody
2024年12月25日 · ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2) is a Protein Coding gene. Diseases associated with ERN2 include Ileocolitis and Inflammatory Bowel Disease. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
ire1 related genes - GeneCards Search Results
Showing 25 of 445 results for ire1 Search Time: 0 ms in Aliases & Descriptions Drugs & Compounds Disorders Text-Mined Disorders Domains Expression in Human Tissues Function Genomics Localization Orthologs Paralogs Pathways Phenotypes Proteins Publications Summaries Transcripts Variants in category Protein Coding RNA Gene Functional Element ...
HSPA5 Gene - GeneCards | BIP Protein | BIP Antibody
2024年12月25日 · Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER).
XBP1 Gene - GeneCards | XBP1 Protein | XBP1 Antibody
2024年12月25日 · It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1).
IRE1A related genes - GeneCards Search Results
Symbol Description Category UniProt ID GIFtS GC id Score; 1: ERN1: Endoplasmic Reticulum To Nucleus Signaling 1: Protein Coding: O75460: 60: GC17M064039: 5.86: 2: HSPA5
TRAF2 Gene - GeneCards | TRAF2 Protein | TRAF2 Antibody
2024年12月25日 · TRAF2 (TNF Receptor Associated Factor 2) is a Protein Coding gene. Diseases associated with TRAF2 include Myeloma, Multiple and Hematologic Cancer. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and signaling …
EIF2AK3 Gene - GeneCards | E2AK3 Protein | E2AK3 Antibody
2024年12月24日 · EIF2AK3 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3) is a Protein Coding gene. Diseases associated with EIF2AK3 include Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus and Menkes Disease .
BFAR Gene - GeneCards | BFAR Protein | BFAR Antibody
2024年12月24日 · Involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Acts upstream of or within negative regulation of apoptotic process.
GeneCards - Human Genes | Gene Database | Gene Search
2024年12月23日 · GeneCards is a searchable, integrative database that provides comprehensive, user-friendly information on all annotated and predicted human genes. The knowledgebase automatically integrates gene-centric data from ~200 web sources, including genomic, transcriptomic, proteomic, genetic, clinical and functional information.