2021年1月1日 · This study aimed to determine the interaction between autophagy and IRE1α-JNK pathway on cell survival in response to ER stress during the initial phase of hepatic steatosis. Methods: Hepatic steatosis was induced in HepG2 cells by supplementing oleic acid (OA). Lipid accumulation was evaluated by BODIPY493/503 staining.

ire1信号通路 UPR条件下，IRE1-JNK帮助细胞自救，是重要的信号通路。 一方面，IRE1活性运动可切割XBP-1 mRNA，使它成为有效的转录激活因子，诱导蛋白基因转录，编码ER分子伴侣，缓解ER压力。

2000年1月28日 · Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which activate chaperone genes in response to ER stress, also activated JNK, and IRE1alpha-/- fibroblasts were impaired in JNK acti …

2019年11月26日 · Our study demonstrates that the induction of eIF2α-CHOP-BCL-2/JNK and IRE1α-XBP1/JNK signaling cascades promote apoptosis and cytokines secretion, and these signaling cascades support NDV...

AKI activates ER stress, and the sensor protein inositol-requiring kinase-1 (IRE1) mediates inflammation by promoting the phosphorylation of C-jun NH2-terminal kinase (JNK). The interleukin-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway is associated with the secretion of renal extracellular matrix (ECM) and ...

在未折叠蛋白反应的三个主要分支中，雷帕霉素选择性抑制 IRE1-JNK 信号传导，而不影响 PERK 和 ATF6 通路。 内质网应激迅速诱导 mTORC1 的激活，这负责诱导 IRE1-JNK 通路和细胞凋亡。 mTORC1 的激活降低了 Akt 磷酸化，这是 IRE-JNK 信号传导和随后的细胞凋亡的上游事件。 在体内，雷帕霉素给药显着抑制了衣霉素处理小鼠的肾小管损伤和细胞凋亡。 它与 Akt 的磷酸化增强和肾脏中 JNK 活性的抑制有关。 这些结果表明，在内质网应激条件下，mTORC1 通过抑制 Akt …

Cab45S increases the GRP78/BiP protein level and prevents GRP78/BiP disassociating from IRE1 during ER stress condition to suppress the IRE1-JNK signaling pathway, and inhibits apoptosis .

In this study, by using an isolated rat heart model to mimic the global myocardial I/R encountered in cardiac surgery, we explored the link between ER stress and sEH by testing the hypothesis that IRE1 induces sEH expression via activation of JNK and c-Jun.

3 天之前 · IRE1-JNK signaling is also implicated in insulin resistance in the liver of patients with type 2 diabetes. On the other hand, the dephosphorylation of GSK3β due to attenuation of Akt phosphorylation contributes to ER stress-mediated β-cell apoptosis .

2022年6月13日 · AKI activates ER stress, and the sensor protein inositol-requiring kinase-1 (IRE1) mediates inflammation by promoting the phosphorylation of C-jun NH2-terminal kinase (JNK). The interleukin-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway is associated with the secretion of renal extracellular matrix (ECM) and ...