The IRE1β-mediated unfolded protein response is repressed by the ...
2023年12月18日 · Here, we exploited the beta isoform of the UPR transducer IRE1, that is specific to mucin-producing cells in order to gauge the relative regulatory roles of activating …
Activation of goblet-cell stress sensor IRE1β is controlled by the ...
2023年12月20日 · We identified the disulfide isomerase and mucin chaperone AGR2 as a goblet cell-specific protein that crucially regulates IRE1β-, but not IRE1α-mediated signaling. AGR2 …
Evolution and function of the epithelial cell-specific ER ... - Nature
2021年6月1日 · Several dedicated molecules with a unique tissue-specific expression in mucosal epithelia govern mucosal homeostasis. Here, we review the biology of Inositol-requiring …
Negative feedback by IRE1β optimizes mucin production in ... - PubMed
2013年2月19日 · Here, we report that IRE1β plays a distinctive role in mucin-secreting goblet cells. In IRE1β(-/-) mice, aberrant mucin 2 (MUC2) accumulated in the ER of goblet cells, …
The IRE1β-mediated unfolded protein response is repressed by the ...
Introduction of the goblet cell-specific client MUC2 reversed AGR2-mediated repression of the IRE1β/α chimera. In vitro, AGR2 actively de-stabilised the IRE1β luminal domain dimer and …
IRE1β evolves to be a guardian of respiratory and gastrointestinal ...
2024年11月15日 · When large amount of unfolded mucin is produced, it triggers AGR2 dissociation of IRE1β, resulting in IRE1β dimerization and activation. Activation of IRE1β may …
T-2 toxin inhibits the production of mucin via activating the IRE1…
2019年8月1日 · We found T-2 toxin induced endoplasmic reticulum stress and activated the IRE1/XBP1 pathway, which may be related to the inhibition of MUC2. Interestingly, T-2 toxin …
Expression of inositol-requiring enzyme 1β is downregulated in ...
2017年1月11日 · IRE1β mRNA expression levels were positively correlated with MUC2 mRNA expression levels. IRE1β expression levels were revealed to be significantly associated with …
Inositol-requiring enzyme 1 (IRE1), a mediator of the unfolded protein response, shows the highest degree of evolutionary conservation. Vertebrates express two IRE1 paralogs: IRE1α, …
IRE1: ER stress sensor and cell fate executor - ScienceDirect
2013年11月1日 · Moreover, IRE1β −/− mice display a distended ER phenotype, potentially due to overaccumulation of Mucin2 (MUC2), the most prominent protein secreted from goblet cells. …