Activation of the IRE1 RNase through remodeling of the kinase …
2020年12月14日 · Inositol-Requiring Enzyme 1 (IRE1) is an essential component of the Unfolded Protein Response. IRE1 spans the endoplasmic reticulum membrane, comprising a sensory …
The Structure, Activation and Signaling of IRE1 and Its Role in ...
Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated upon …
Decoding non-canonical mRNA decay by the endoplasmic …
2021年12月15日 · IRE1 helps mitigate endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved sequence endomotif via regulated IRE1-dependent decay (RIDD).
The Structure, Activation and Signaling of IRE1 and Its Role in ...
2021年2月5日 · Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three branches of the Unfolded Protein Response (UPR) signaling pathway, which is …
Mammalian IRE1α dynamically and functionally coalesces with …
2024年5月7日 · Here we report that, in mammalian cells, formation of IRE1α clusters is an ER membrane-bound phase separation event that is coupled to the assembly of stress granules …
刘勇课题组揭示未折叠蛋白响应分子IRE1α与应激颗粒共聚集的动 …
2024年5月8日，武汉大学生命科学学院刘勇教授课题组在Nature Cell Biology杂志上在线发表了题为“Mammalian IRE1α dynamically and functionally coalesces with stress granules” 的研究论 …
Structural and functional basis for RNA cleavage by Ire1
2011年7月6日 · Central to this signaling pathway is the ER-resident bifunctional transmembrane kinase/endoribonuclease Ire1. The endoribonuclease (RNase) domain of Ire1 initiates a non …
Exploring the IRE1 interactome: From canonical signaling …
IRE1 first appeared as a transducer of the UPR, in order to restore a balance in ER homeostasis and help cells adapt to stress. The evolutive interactome unveils possible new roles of IRE1 in …
Structure of the Ire1 autophosphorylation complex and …
In the endoplasmic reticulum, unfolded proteins stimulate Ire1 autophosphorylation and RNase activity. The crystal structure of the dephosphorylated kinase/RNase domain of human Ire1 …
国际期刊|IF21.3！武汉大学刘勇团队首次揭示内质网应激关键分 …
肌醇需要酶1（IRE1）是位于内质网上的跨膜蛋白，IRE1是从酵母到哺乳动物保存的最古老的内质网应激传感器，具有一个N端内质网管结构域 (LD)，用于检测未折叠/错误折叠的蛋白质负 …