Inputs from IRE1 and IKK, in combination with translation repression by PERK, another UPR initiator, lead to maximal NF-κB activation during the UPR. These interdependencies have a significant impact in cancer cells with elevated IKK/NF …

2012年10月26日 · The Kinase Activity of IRE1 Is Required for NF-κB Activation During ER Stress. Since cells lacking IRE1 showed severely decreased NF-κB during UPR, and IRE1 is a multi-functional protein, we wanted to examine the importance of IRE1 kinase and RNase activities.

NF-κB activity inversely correlates with CHX-mediated translational inhibition, showing a proportional correlation with the level of NF-κB activation. Based on these genetic experiments, IRE1α-dependent regulation of basal IKK activity is necessary for …

近年有研究发现ire1α可以促进胞质nf-κb抑制剂iκb降解，加速nf-κb转位至细胞核，诱导多种炎症因子基因表达，促进血管内皮炎症和功能障碍 [13] 。 在本实验中，我们观察到ERS标志蛋白GRP78升高，同时还发现IRE1α、NF-κB表达均升高，表明SAH后ERS被触发，并激活IRE1α ...

In this study, we show that IRE1 is involved in the activation of NF-kB induced by ER stress. NF-kB was activated by ER stress-inducing agents, thapsigargin and tunicamycin. The activation was inhibited by a dominant-negative IRE1. In addition, a dominant-negative TRAF2 also suppressed the activation of NF-kB by ER stress.

2011年11月21日 · On the other hand, NF-κB can be intrinsically activated during ER stress response, mainly by Ire1-TRAF2 complex of UPR recruiting IκB kinase (IKK) (Zhang and Kaufman, 2008), and ER stress...

In this study, we show that IRE1 is involved in the activation of NF-kappaB induced by ER stress. NF-kappaB was activated by ER stress-inducing agents, thapsigargin and tunicamycin. The activation was inhibited by a dominant-negative IRE1. In addition, a dominant-negative TRAF2 also suppressed the activation of NF-kappaB by ER stress.

2022年7月15日 · Our previous study showed that altered Txnrd3 expression can cause ER stress via up-regulated expression of IRE1 and PERK in Txnrd3− /− mice than Wild mice (p < 0.01), which was more significant after Ni exposure (p < 0.01) and elevated IRE1 expression increased its downstream gene NF-kB, and NF-kB upregulates NLRP3 expression as an ...

Inputs from IRE1 and IKK, in combination with translation repression by PERK, another UPR initiator, lead to maximal NF-kB activation during the UPR. These interdependencies have a significant impact in cancer cells with elevated IKK/NF …

IRE1（Immunoglobulin-Regulated Enhancer 1）是一种转录因子，主要参与免疫细胞的生长和活化。 IRE1在多种免疫细胞中表达，包括T细胞、B细胞、巨噬细胞和树突状细胞等。