eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote …
2019年11月26日 · Our study demonstrates that the induction of eIF2α-CHOP-BCL-2/JNK and IRE1α-XBP1/JNK signaling cascades promote apoptosis and cytokines secretion, and these …
详解内质网应激/未折叠蛋白反应三条信号通路 - 简书
2020年8月8日 · IRE1α首先发生磷酸化，并形成二聚体。 p-IRE1α接下来会催化一个重要的过程：使Xbp1 mRNA发生剪切，形成一个功能活跃的转录因子Xbp1s。 Xbp1s进入细胞核后会启 …
Science | 发现全新的决定内质网应激下细胞命运的调控因子 - 知乎
后续的研究证明，QRICH1是属于UPR PERK-eIF2a通路的关键效应因子，其翻译受到QRICH1 mRNA上游开放阅读框的调控。 通过结合RNA-seq和染色质免疫沉淀测序 (ChIP-seq)的结 …
eIF2α phosphorylation is pathognomonic for immunogenic cell …
2018年1月22日 · Active IRE1 possesses in its cytoplasmic domain an endoribonuclease function allowing it to excise an intron of 26 nucleotides from the mRNA of the transcription factor X …
The eIF2 kinase PERK and the integrated stress response ... - PubMed
Three ER stress sensors (PERK, ATF6, and IRE1) implement the UPR. PERK phosphorylation of the α subunit of eIF2 during ER stress represses protein synthesis, which prevents further …
Novel mechanism of enhancing IRE1α-XBP1 signalling via the …
2016年4月7日 · In this study, we found that IRE1α was induced by ER stress both in vivo and in cultured cells. Using various knockout cells, we revealed that the increase in IRE1α …
To prevent a further increase in protein-folding demand in the ER, PERK tran-siently inhibits general protein translation through phos-phorylation of eukaryotic initiation factor 2 alpha …
Role of eIF2α Kinases in Translational Control and Adaptation to ...
Key themes in the review will be the mechanisms regulating eIF2α kinases, the role that upstream open reading frames (uORFs) play in translational control, and the impact that altered P-eIF2α …
内质网应激相关激酶PERK有什么重要作用？（Cancer Cell）
2022年11月24日 · 蛋白激酶R（PKR）样内质网激酶（PERK）是四种已知的激酶之一，通过激活真核细胞起始因子2α（eIF2α）或其他信号转导级联来响应细胞应激。 PERK在胰腺β细胞中 …
The eIF2 kinase PERK and the integrated stress response facilitate ...
2011年9月14日 · ER stress activates three transmembrane proteins—ATF6, IRE1 (ERN1), and PERK (PEK/EIF2AK3)—which together induce the unfolded protein response (UPR), involving …