IRE1α (14C10) Rabbit mAb | Cell Signaling Technology
Monoclonal Antibody for studying IRE1. Validated for IP, WB, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, IRE1α (14C10) Rabbit Monoclonal Antibody (CST #3294) is ready to ship.
Anti-IRE1 antibody. Rabbit polyclonal (ab37073) - Abcam
The inositol-requiring enzyme 1 (IRE1) also known as ERN1 or IRE1 alpha is a critical endoplasmic reticulum (ER) stress sensor. It has a molecular weight of approximately 110 kDa. IRE1 is expressed in various cell types and tissues particularly in those subject to a high degree of protein synthesis such as the liver pancreas and secretory cells.
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Anti-IRE1抗体(ab37073) - Abcam中文官网
Observed band size: 110 kDa Diluting buffer and concentration: 1 hour incubation at room temperature in 5% NFDM/TBST. Beta-actin antibody (1 μg/mL) used as loading control.
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IRE1; ERN1 antibody (27528-1-AP) | Proteintech - ptglab
Inositol-requiring enzyme 1 (IRE1) is an ER transmembrane sensor that activates the UPR to maintain the ER and cellular function. Although mammalian IRE1 promotes cell survival, it can initiate apoptosis via decay of antiapoptotic miRNAs.
Anti-IRE1抗体(ab235171) - Abcam中文官网
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...
Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein response (UPR) signal transducer during endoplasmic reticulum functional upset (ER stress). A IRE1α signal pathway arbitrates yin and yang of cellular fate in objectionable conditions.
IRE1 alpha Antibody - BSA Free - Novus Biologicals
IRE1 alpha is a transmembrane protein that has both serine-threonine kinase and endoribonuclease activities and has a theoretical molecular weight of 110 kDa. When detecting phospho-IRE1 alpha, it is recommended to normalize its band intensity with total IRE1 alpha.
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The ADP-binding kinase region of Ire1 directly contributes to its ...
2021年2月24日 · Ire1 is an ER-located type-I transmembrane protein that acts as an ER-stress sensor to trigger the UPR and is conserved throughout eukaryotic species. The cytosolic domain of Ire1 has two...
Novel insight on IRE1 in the regulation of chondrocyte ...
2024年2月10日 · Chondrocytes transfected with the cDNA of IRE1 reduced the expression of type II collagen, disrupting chondrocyte differentiation as confirmed by western blotting and immunofluorescence. Upon siRNA treatment, the influence of IRE1 on chondrocyte differentiation is restored by reviving the normal expression of type II collagen.
Protein Disulfide Isomerase A6 Controls the Decay of IRE1α …
2014年2月20日 · Here, we demonstrate a mechanism that attenuates the activity of the UPR sensor inositol-requiring enzyme 1α (IRE1α). A resident ER protein disulfide isomerase, PDIA6, limits the duration of IRE1α activity by direct binding to cysteine 148 in the lumenal domain of the sensor, which is oxidized when IRE1 is activated.