2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial...

2023年8月9日 · IRF7 is a lymphoid-specific factor that is predominantly expressed in the cytoplasm of the spleen, thymus, and peripheral blood lymphocytes, such as B cells, …

Overexpression of IRF7 increased IFN-β production and thus significantly enhanced NK cell activity, leading to cytolysis of prostate cancer target cells and exerting an inhibitory effect on …

2025年2月4日 · Mechanistic studies guided by single-cell-RNAseq and ChIPseq reveal that IRF7 promotes B cell differentiation through germinal center and plasma cell fates by regulating the …

2005年3月30日 · The type-I interferon (IFN-α/β) response is critical to immunity against viruses and can be triggered in many cell types by cytosolic detection of viral infection, or in …

2023年9月21日 · The blue module relevant to memory B cells was most significantly enriched in the "defence response to virus" correlation pathway. Then we screened six hub genes by PPI …

When this receptor is stimulated in normal B cells it causes an increased expression of interferon regulatory factor 7 (IRF7), which is a crucial regulator of type I interferons in pathogenic …

2024年10月9日 · IRF2 is constitutively expressed in multiple cell types and its expression can be further induced by viruses and IFN. Despite sharing a similar DBD with IRF1, IRF2 frequently …

2025年1月15日 · IRF3, IRF7, and STAT1 play crucial roles in type I IFN production in neutrophils, dendritic cells, and T cells. MYB acts as a key regulator in T cell activation, promoting …

2025年2月4日 · Mechanistic studies guided by single-cell-RNAseq and ChIPseq reveal that IRF7 promotes B cell differentiation through germinal center and plasma cell fates by regulating the …

2023年8月10日 · In this review, we provide a comprehensive overview on the current knowledge of the role of IRF7 in immunity and autoimmunity. We focus on the latest regulatory …

IRF7 from the Australian black flying fox Pteropus alecto, has been highlighted as a potent regulator of interferon alpha (IFNα). Unlike the restriction to lymphoid cells/monocytes seen in …

2025年2月8日 · Mechanistic studies revealed that IRF7 promoted B cell differentiation through GC and PC fates by regulating the transcriptome, translation, and metabolism of SLE-prone B …

2015年1月2日 · We have found that knockdown of IRF7 leads to growth inhibition of EBV-transformed cells, and restoration of IRF7 by exogenous plasmid correlates with growth …

Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I interferons (IFNs) …

Interferon regulatory factor 7 (IRF7) has been shown to be highly expressed in nasal aspirates from children with asthma. Type 2 innate lymphoid cells (ILC2s) represent the major player in …

Further analysis revealed that IRF7 was significantly associated with the abundance of immune cells (B cells, Neutrophils and Dendritic cells) and the expression of most immune biomarkers. …

2020年11月3日 · IRF7 from the Australian black flying fox Pteropus alecto, has been highlighted as a potent regulator of interferon alpha (IFNα). Unlike the restriction to lymphoid …

2025年3月5日 · Single-cell transcriptome aging clocks predict biological age. We developed immune cell-type-specific transcriptome aging clocks, sc-ImmuAging, for human PBMCs (Fig. …

As the mechanisms that Irf7 axis enhances vaccine effectiveness, IFNγ-producing not T or NK cells but B cells enhanced anti-tumor immune responses. Because of some unclear points, …