Additionally, seven highly populated biological pathways with the IRDS genes were identified, and with recording their frequently associated genes (IFIT1/3, IFITM1, IRF7, ISG15, MX1/2 and …

2018年5月16日 · In this Review, we describe new insights into how ISG15 directly inhibits viral replication and discuss the recent finding that ISG15 modulates the host damage and repair …

Interferon-stimulated gene 15 (ISG15) plays an important antiviral role during viral infection. ISG15 catalyzes a ubiquitin-like post-translational modification termed ISGylation, involving the …

2021年10月20日 · In this issue of Nature Immunology, Sanyal and colleagues show that SARS-CoV-2 infection of human macrophages induces the release of intracellular ISG15 (interferon …

2019年3月12日 · Several ISGs, including IFIT1, IFIT2, IFIT3, Mx1, Mx2, CXCL10 and ISG15 were found to be upregulated transcriptionally following HCMV infection independently of type I IFN …

The ubiquitin-like protein ISG15 is one of the most significantly up-regulated host factors in HIV-infected patients, inhibiting the budding and release of HIV...

2015年8月11日 · Listeria-mediated ISG15 induction depends on the CSP, which senses bacterial DNA and signals through STING, TBK1, IRF3, and IRF7. Most importantly, we demonstrate …

2023年12月1日 · ISG15 in its unconjugated (free) form fine-tunes intracellular signaling cascades and, upon extracellular secretion, functions ‘cytokine-like’, contributing to immunomodulation. …

2023年5月5日 · Interferon stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is highly induced upon activation of interferon signaling and cytoplasmic DNA sensing pathways. …

2018年2月1日 · Interferon (IFN)-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is heavily involved in immune response elicitation. As an important member of interferon …