2012年12月14日 · IFN-induced protein with tetratricopeptide repeats (IFIT) proteins — which are induced after type I interferon (IFN)- or IFN-regulatory factor 3 (IRF3)-dependent signalling — …

摘要: IFIT1是一种高度诱导的具有四肽重复序列的干扰素刺激基因家族 (ISGs)成员，主要存在于细胞质，其表达受干扰素 (IFN)、多种病毒和某些病原体相关分子模式的调节，具有抗病毒、抗 …

Activated IRF3 can induce ISGs directly, in the absence of IFN production, or co-operate with additional transcription factors such as IRF1, IRF7 and NF- κ B to elicit type 1 IFN production.

IRF1, IRF3 and IRF7 are capable of inducing ISGs in an IFN-independent manner as reported for the STAT independent expression of ISGs including beta 2- microglobulin (β2m), guanylate …

In addition to IRF9, other IRF transcription factor family members (e.g., IRF1, IRF3, and IRF7) induce IFITM expression independent of the STAT pathway (53, 54). Moreover, in addition to …

该基因编码一种含有四肽重复序列的蛋白质，最初被鉴定为在干扰素处理后被诱导产生。 编码的蛋白质可以抑制病毒复制和翻译起始。 该基因与其他五个密切相关的基因位于 10 号染色体上的 …

2014年10月1日 · IFIT1 can detect viral RNA lacking 2 ′ -O methylation on their cap structures or displaying a 5′-triphosphate moiety and inhibit their translation or sequester them from active …

IFIT1 binds tightly to non-self RNA, particularly capped transcripts lacking methylation on the first cap-proximal nucleotide, and inhibits their translation by out-competing the cellular...

IFN-induced protein with tetratricopeptide repeats (IFIT) proteins — which are induced after type I interferon (IFN)- or IFN-regulatory factor 3 (IRF3)-dependent signalling — contribute to …

Adapter proteins MYD88, TRIF and ISP-1 are used by the receptor complex that activate IRF3 and IRF7 by phosphorylaton, which then bind the DNA to stimulate IFN expression. Secreted …