2016年1月25日 · Our findings demonstrate that IRF7 regulates the expression of genes involved in antiviral immunity, inflammation, and the response to oxidative stress during HRV infections in HBE cells, and also suggests that other transcription factors play a major role in this response.

In vivo infection studies were performed by injecting mice with anti-CCL7 antibody/isotype control, IRF7-siRNA/control siRNA. IRF7 promoted IFN-α and IFN-β production, as well as neutrophil and macrophage infiltration in combination with CCL7, thus …

We identify the transcription factor interferon regulatory factor 7 (IRF-7), a heterodimer partner of IRF-3, as a target for non–antibiotics-based therapy of bacterial infections. We found that the efficient and self-limiting innate immune response to bacterial infection relies on a tight balance between IRF-3 and IRF-7.

2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial...

At the Irf7 promoter, SRSF7 maximizes STAT1 transcription factor binding and RNA polymerase II elongation via cooperation with the H4K20me1 histone methyltransferase KMT5a (SET8). These studies define a role for an SR protein in activating transcription and reveal an RBP-chromatin network that orchestrates macrophage antiviral gene expression.

In lung epithelial cells, type I and III IFN induction by IAV is dependent on RIG-I and TLR3 activation. To examine the role of IRF7 induction in this process, we first examined the effect of IRF7 knockdown by specific siRNA on IRF7 mRNA induction by IAV PR8. IAV induced IRF7 mRNA 360 fold over the levels seen in mock-infected cells.

We demonstrate that transcriptional repression of IRF7 by MYC provides an additional layer of tight regulation of IRF7 that ensures the appropriate level of type I IFN production and prevents the development of autoimmune disease. Combination studies have identified the IRF7 gene as a critical target of MYC, although not its only target.

2025年2月8日 · SiRNA-mediated inhibition of IRF7 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes in immature dendritic cells and in monocyte-derived macrophages: PubMed: tat: HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells: PubMed: Vpr: vpr

IRF7 Human Pre-designed siRNA Set A contains three designed siRNAs for IRF7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control. Components IRF7 siRNA-1: 5 nmol (HPLC)

2016年7月14日 · We show that lipid-based reagent DOTAP was extremely efficient for siRNA delivery into pDC and did not induce cell death or pDC activation. We successfully silenced Toll-Like Receptor 7 (TLR7),...