ACO1, or IRP1, is a bifunctional protein that functions as an iron-responsive element (IRE)-binding protein involved in the control of iron metabolism by binding mRNA to repress translation or degradation. It functions also as the cytoplasmic isoform of aconitase.

Iron regulatory protein 1 (IRP1/ACO1) is a bifunctional protein present in the cytoplasm that re-sponds to cytosolic iron status mainly through an iron-sulfur switching mechanism, alternating between an active cytosolic ubiquinone form with an iron-sulfur cluster attached to its active site and a decofactorized protein form that binds iron ...

IRP1是一种双功能酶，在细胞内铁富足的情况下，IRP1获得铁硫簇，发挥乌头酸酶活性，参与线粒体呼吸。 而当细胞内铁不足时，IRP1失去铁硫簇，与IRE结合，参与细胞内铁稳态的调节。 不同于IRP1，IRP2没有铁硫簇，不具有乌头酸酶活性，其活性通过泛素介导的蛋白降解途径调节。

2006年7月18日 · Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron...

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in …

铁调节蛋白1 (IRP1/ACO1) 是存在于细胞质中的双功能蛋白质,主要通过铁–硫开关机制来反应细胞溶质铁状态,在具有连接到其活性位点的铁–硫簇的活性细胞溶质乌头酸酶形式和结合铁反应元件的脱辅基蛋白形式之间交替,但不存在量的变化。 相关研究表明铁调节蛋白1 (IRP1/ACO1)通过调控低氧诱导因子2α 以及铁下垂等过程在多种疾病的发生发展进程中发挥重要作用。...

2011年11月24日 · Iron regulatory proteins (IRPs) 1 and 2 are RNA-binding proteins that control cellular iron metabolism by binding to conserved RNA motifs called iron-responsive elements (IREs). The currently known IRP-binding mRNAs encode proteins involved in iron uptake, storage, and release as well as heme synthesis.

2019年11月29日 · Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor. When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with...

2022年9月15日 · Iron regulatory protein 1 (IRP1) is a bifunctional protein with mutually exclusive RNA-binding or enzymatic activities that depend on the presence of a 4Fe-4S cluster. While IRP1 is a well-established cytosolic protein, work in a Drosophila model suggested that it may also exhibit nuclear localizati …

IRP1 can assume two different functions in the cell, depending on conditions. During iron scarcity or oxidative stress, IRP1 binds to mRNA stem-loop structures called iron responsive elements (IREs) to modulate the translation of iron metabolism genes. In iron-rich conditions, IRP1 binds an iron-sulfur cluster to function as a cytosolic aconitase.