ITK (IL-2-inducible tyrosine kinase) belongs to the Tec family kinases and is mainly expressed in T cells. It is involved in TCR signalling events driving processes like T cell development as well as Th2, Th9 and Th17 responses thereby controlling the expression of pro-inflammatory cytokines.

2020年8月18日 · Interleukin-2-inducible T cell kinase plays a central role in the signal transduction of the T cell receptor. By binding of the MHC to the TCR, the kinase Lck (lymphocyte-specific protein tyrosine kinase) becomes activated with the help of Zn 2+.

2024年11月26日 · IL-2-inducible T cell kinase (ITK) is a critical modulator of the strength of T cell receptor signaling, while its role in CAR signaling is unknown. By electroporation of CRISPR-associated protein 9 (Cas9) ribonucleoprotein (RNP) complex into CAR-T cells, we successfully deleted ITK in CD19-CAR-T cells with high efficiency.

该基因编码在 T 细胞中表达的细胞内酪氨酸激酶。 该蛋白质包含 SH2 和 SH3 结构域，这两个结构域通常存在于细胞内激酶中。 它被认为在 T 细胞增殖和分化中发挥作用。 [RefSeq 提供，2008 年 7 月] This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases.

2020年8月18日 · ITK (IL-2-inducible tyrosine kinase) belongs to the Tec family kinases and is mainly expressed in T cells. It is involved in TCR signalling events driving processes like T cell development as well as Th2, Th9 and Th17 responses thereby controlling the expression of pro-inflammatory cytokines.

IL2-inducible T cell kinase (Itk) is part of the Tec family of tyrosine kinases and is a critical component of T cell receptor mediated signaling. Here, we showed that either genetic ablation of Itk signaling or inhibition of Itk signaling pathways resulted in increased frequency of "noncanonical" CD4 + CD25 - FOXP3 + Tregs (ncTregs), as well ...

Itk (Interleukin-2-inducible T-cell kinase) is a Tec family tyrosine kinase that mediates signaling processes after T cell receptor engagement. Activation of Itk requires recruitment to the membrane via its pleckstrin homology domain, phosphorylation of Itk by the Src kinase, Lck, and binding of Itk to the SLP-76/LAT adapter complex.

2024年12月2日 · 该研究发现，IL-2诱导T细胞激酶（ITK）可以作为基因敲除或抑制的靶点，通过敲除或抑制ITK，促进CAR-T细胞的体内存活，从而更有效地控制肿瘤复发。 此项研究为开发更具持久性的CAR-T细胞疗法提供了新的潜在策略。 嵌合抗原受体T细胞疗法（CAR-T）作为一种突破性的细胞免疫疗法，已广泛应用于治疗白血病等多种癌症。 目前，已有10种CAR-T产品获得临床治疗批准。 尽管CAR-T疗法在白血病治疗中取得了显著疗效，但其在临床实践中仍面临诸多挑 …

ITK is a key signaling mediator downstream of TcR, mediating T cell positive selection, innate T cell and CD4 + Th2/Th17 differentiation. Here we show that ITK also negatively tunes IL-2-induced expansion of Foxp3 + regulatory T cells (Treg).

2021年8月20日 · IL-2-inducible T cell kinase (ITK) is essential for proximal T cell receptor (TCR) signaling. Following TCR ligation, ITK is recruited to the cell membrane where it interacts with Linker for activation of T cells (LAT) and SH2-domain-containing leukocyte protein of 76 kDa (SLP76) (Qi et al., 2006; Bunnell et al., 2000).