Unlike nearly all other benzodiazepine conversions, the conversion between intravenous midazolam and lorazepam has been well studied in mechanically ventilated patients. 16 A commonly cited double-blind trial suggests a conversion of 1 mg IV lorazepam to 2 mg of IV midazolam, which is further supported using a midazolam oral bioavailability of ...

Non-IV BDZ, compared to IV BDZ, terminate seizures faster and have a superior efficacy and side effect profile. Higher-quality studies and further evaluation in different age groups are warranted.

Market Aim: Although all benzodiazepines have similar actions, they are usually marketed as anxiolytics (a), hypnotics (h) or anticonvulsants (e). In the UK clobazam (Frisium) and clonazepam (Rivotril) are licensed for use as anti-epileptics only.

The benzodiazepine conversion calculator adjusts doses between converting oral benzodiazepines.

Remimazolam (CNS7056) is a new ultra-short-acting intravenous (IV) BDZ developed by the pharmaceutical company PAION AG and acts on γ-aminobutyric acid type A (GABA A) receptors. 10 Owing to its “soft drug” (self-metabolising and organ-independent) design, it is rapidly hydrolyzed in the body as an inactive carboxylic acid (CNS7054) by tissue es...

2017年9月15日 · BZDs are first-line agents for termination of seizures in status epilepticus. If IV access is available, lorazepam 4 mg IV (0.1 mg/kg IV, in children, max 4 mg) should be administered, and repeated in 5 minutes as needed. Onset of action is within 2 minutes, and duration is 4-6 hours.

2017年3月25日 · Non-IV BDZ, compared to IV BDZ, terminate seizures faster and have a superior efficacy and side effect profile. Higher-quality studies and further evaluation in different age groups are warranted.

2015年5月31日 · BZD作用於中樞神經系統 GABA-A受體上的 benzodiazepine receptor，增加神經元細胞膜氯離子的通透性，造成超極化的不反應狀態，達到神經抑制的作用。 表格中把院內有的口服 BZD品項從較短效的 Brotizolam (短效多記一個院內只有針劑的 Midazolam)，到中效的 Lorazepam, Alprazolam至長效的 Fludiazepam, Diazepam由上到下排列，適應症大同小異，幾乎都是焦慮或失眠，除了 Clonazepam為癲癇治療用。 起始作用時間約半小時。

compared the IV administration of a BDZ (of any kind) as treatment for status epilepticus with that of a rectal, buccal, intranasal (IN), or intramuscular (IM; non-IV) BDZ of any kind. We included studies on both pediatric and adult populations in our analysis. In addition, we did not restrict our review to the English language.

2021年11月21日 · Objective: To assess the efficacy, safety, and acceptability of intranasal midazolam in children with acute seizure when compared to conventional IV or rectal benzodiazepine (BDZ). Methods: PubMed, google scholar, websites clinicaltrials.gov and the WHO-international clinical trials registry platform, were searched.