Advances in science have made possible the derivation of reproductively viable gametes in vitro from mice. The research on human cells suggests that in vitro gametogenesis (“IVG”) with reproductive potential may one day be possible with humans.

2023年10月19日 · In vitro–derived gametes are generated using pluripotent stem cells (PSCs) through a process called “in vitro gametogenesis” (IVG). The stem cells used can be embryonic stem cells (ESCs) derived from preimplantation embryos or somatic cells that have been reprogrammed into induced PSCs (iPSCs).

In IVG, pluripotent stem cells are differentiated into primordial germ cell-like cells (PGCLCs). PGCLCs are then directed along pathways that PGCs follow as they develop and mature in the body. The stem cell origin of PGCLCs is particularly significant when considering the clinical applications of IVG.

2025年2月26日 · In vitro gametogenesis or IVG is a laboratory method to create gametes, meaning sperm or eggs, from stem cells. For thousands of years, humans have only been making sperm and eggs inside our bodies. However, new stem cell technologies have made laboratory or “in vitro ” gamete formation possible.

We distinguish three broad clinical applications of IVG: opposite‐sex reproduction, same‐sex reproduction, and solo reproduction. For simplicity, we focus on the use of IVG for couples or individuals of normal reproductive age.

2023年8月30日 · In vitro gametogenesis (IVG) is the means of developing gametes —reproductive cells like sperm or eggs—outside of the body. In theory, doctors could take any cell from your blood, skin or hair; reprogram it in a lab to become a gamete and then use that to create fertilized embryos that would eventually be implanted into a uterus.

被称为ivg的技术是体外配子发育的缩写，通过这项技术，同性伴侣可以用自己的遗传基因而非他人的来孕育婴儿。 具体办法是让自己的体细胞变成 ...

In vitro gametogenesis (IVG), the creation of eggs and sperm from non-reproductive cells, such as skin cells, or embryonic stem cells, has the potential to revolutionise human reproduction.

2023年10月19日 · The National Academies Board on Health Sciences Policy hosted a workshop in April 2023 to explore the development of in vitro-derived human eggs and sperm from pluripotent stem cells through a process known as in vitro gametogenesis (IVG).

In vitro gametogenesis (IVG) reprograms a person’s blood or skin cells back into an embryonic-like state — these “induced pluripotent stem cells” (iPSCs) can then be coaxed into becoming sperm or eggs, which could then create embryos with IVF.