Allograft inflammatory factor 1 (AIF-1) also known as ionized calcium-binding adapter molecule 1 (IBA1) is a protein that in humans is encoded by the AIF1 gene. [5][6] The AIF1 gene is located within a segment of the major histocompatibility complex class III region.

2021年2月4日 · To evaluate whether Iba-1 protein expression could be used as a sensitive marker for microglial activation, we characterized microglial activation both in vivo and in vitro by examining the expressions of Iba-1, CD-11b, F4/80, as well as inflammatory factors.

离子钙结合衔接分子 1 (Iba1) 是小胶质细胞和巨噬细胞特异性的钙结合蛋白，参与激活的小胶质细胞的细胞膜皱褶形成和吞噬作用。 经抗-Iba1 ( ab5076 ) 抗体染色的小鼠脑组织切片。

2021年6月17日 · IBA1 is a novel, highly sensitive, and specific marker for diagnosing neoplasms of monocytic/histiocytic and DC origin.

iba1（离子钙结合适配分子1），也被称为同种异体移植炎症因子1（aif1），是一种进化上保守的细胞浆钙结合蛋白。 IBA1是巨噬细胞存活所必需的，也是促炎活性的关键分子（PMID: 29749461）；它参与活化小胶质细胞/巨噬细胞状态相关的形态变化，因此被广泛用作 ...

4 天之前 · IBA1 is a defining marker for myeloid-lineage cells, particularly microglia and macrophages, due to its exclusive expression in these populations. Unlike markers shared across multiple immune cell types, IBA1 effectively distinguishes myeloid cells …

Iba1 is a reliable cytoplasmic microglial marker with a strong signal, labelling both cell bodies and processes (Fig. 3, Step 1, Supplementary Fig. 2a). Nevertheless, there is a major pitfall in using this marker, since Iba1 does not exclusively label microglia cells.

Iba1 is a marker for microglial cells and previous immunocytochemical studies have utilized this and other microglial-specific antibodies to demonstrate the morphological features of microglial cells at the light microscopic level.

2020年7月16日 · We therefore undertook an immunohistochemical analysis of seven markers whose expression by Iba1-positive cells can be used to infer a wider range of cell functions in the post-mortem human...

IBA1/AIF-1 是一种进化上保守的钙结合蛋白。 作为 F-肌动蛋白结合蛋白，Iba1/AIF-1 可能会重塑小胶质细胞的肌动蛋白细胞骨架。 Iba1/AIF-1 在单核细胞谱系的细胞中独特表达，因此，靶向该蛋白的抗体被广泛用于标记大脑和其他组织中的小胶质细胞/巨噬细胞。 Iba1/AIF-1 (E4O4W) XP® Rabbit mAb #17198： 使用 Iba1/AIF-1 (E4O4W) XP ® Rabbit mAb #17198（绿色）对人皮层（左图）和小鼠 CA1 海马（右图）进行共聚焦免疫荧光分析。 在小鼠组织切片中，细胞核标有 …