ICOS + Tregs: A Functional Subset of Tregs in Immune Diseases - PubMed
2020年8月28日 · In this review, we discuss the complicated role of ICOS + Tregs in several classical autoimmune diseases, allergic diseases, and cancers and investigate the related therapeutic applications in these diseases. Moreover, we identify ICOS as a potential biomarker for disease treatment and prognostic prediction. In addition, we believe that anti ...
ICOS + Tregs: A Functional Subset of Tregs in Immune Diseases
In this review, we discuss the complicated role of ICOS + Tregs in several classical autoimmune diseases, allergic diseases, and cancers and investigate the related therapeutic applications in these diseases. Moreover, we identify ICOS as a potential biomarker for disease treatment and prognostic prediction.
诱导型T细胞共刺激因子ICOS - mabnus.cn
2024年8月22日 · 诱导性t细胞共刺激因子（icos，cd278）是一种激活性共刺激免疫检查点，在活化的t细胞上表达。 可诱导T细胞的增殖、存活和分化，并调节多种T细胞功能。
Regulatory T cells, especially ICOS - Nature
2016年10月11日 · According to whether or not they express inducible costimulator (ICOS), Tregs can be divided into ICOS + and ICOS − Tregs. In vitro experiments have confirmed that the capacity of cytokine...
ICOS靶点能否成为肿瘤免疫治疗的新星？ - 知乎专栏
多种疾病的动物模型研究表明，可诱导共刺激受体（ICOS）在自免和肿瘤免疫中都有应用，并且以ICOS途径为靶点的免疫调节对包括自身免疫性疾病及移植免疫的长期耐受的形成，均有着重要的临床应用意义。 ICOS与其配体的结合触发下游通路，从而调节T细胞增殖和存活，这表明ICOS可作为预测和监测T细胞介导的免疫治疗反应的生物标志物。 同时，ICOS的共刺激受体激动剂有望克服诸如 PD-1 抗体、 CTLA-4 抗体等现有免疫疗法临床应用的局限性，成为一种可提高肿瘤免疫 …
ICOS + Tregs：免疫疾病中Tregs的功能子集。,Frontiers in …
Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) cells. The ICOS signaling pathway endows Tregs with increased generation, proliferation, and …
Inducible costimulator (ICOS) is a marker for highly suppressive ...
High levels of inducible costimulator (ICOS) expression defined a population of CD4 (+)CD25 (+)FoxP3 (+) (forkhead box protein 3) Treg cells that presented superior suppressive activity. Importantly, ICOS (+) Treg cells were distinguishable from all other FoxP3 (+) Treg cells by the expression of IL-10, IL-17, and IFN-gamma.
可诱导T细胞共刺激分子：免疫刺激或免疫抑制的目标？
2018年3月13日 · 由于在维持T细胞活化和效应因子功能以及其与Treg抑制关系中的双重作用，靶向ICOS/ICOS-L代表了增强抗肿瘤免疫性的有效方法。 在临床中，结肠癌患者表现出ICOS的下降，而肿瘤中ICOS的表达与黑素瘤患者更高的存活率相关。
In this review, we discuss the complicated role of ICOSC Tregs in several classical autoimmune diseases, allergic diseases, and cancers and investigate the related therapeutic applications in these...
ICOS Regulates the Generation and Function of Human CD4 + Treg …
2013年12月2日 · Here we investigate the role of ICOS in the generation and function of CD4 hi Treg by interrupting ICOS-ICOSL interaction with ICOS-Ig. It is found that blockade of ICOS-ICOSL interaction impairs the induction and expansion of CD4 hi Treg induced by allogeneic CD40-activated B cells.