2015年1月8日 · How follicular T-helper (TFH) cells regulate GC selection is not clear. Using competitive mixed chimaera, we show here that, beyond the role in promoting TFH development, ICOSL (inducible T-cell co-stimulator ligand, also known as ICOSLG) is important for individual B cells to competitively participate in the GC reaction and to develop into BMPCs.

2015年3月6日 · MiR-146a represses several Tfh-cell-expressed messenger RNAs, and of these, ICOS is the most strongly cell autonomously upregulated target in miR-146a-deficient T cells. In...

2018年3月15日 · Our results suggest that ApoAI reduces the exTreg to Tfh generation through maintenance of IL-2R expression on Treg cells and reduction of IL-6, resulting in reduced Bcl6 expression, correcting...

Our results reveal a mechanistic role of AIRE-BMDCs in the initiation of T FH cell differentiation, and the AIRE-mediated decrease in ICOSL expression in BMDCs plays a critical role. The effect of decreased ICOSL expression in type 1 diabetes will guide the design and evaluation of parallel studies in patients.

2014年10月15日 · By demonstrating entanglement as the basic form of GC T FH –B-cell interactions, identifying ICOSL as a molecular linkage between T–B interactional dynamics and positive selection for...

Recent data have shown that OX40/OX40L signaling can not only promote Tfh cell differentiation and maintain cell survival, but also enhance the helper function of Tfh for B cells. Moreover, upregulated OX40 signaling is related to abnormal Tfh activity that causes autoimmune diseases.

2016年9月6日 · 通过使用多种基因工程小鼠模型，结合经典细胞免疫学手段与双光子在体内实时成像技术，祁海教授研究小组的研究显示，ICOS通过PI3K信号诱导细胞伪足发生，促进T细胞在体内的持续性运动能力。 在淋巴器官滤泡区，B细胞组成性表达 ICOS的配体（ICOSL），从而通过持续刺激ICOS信号使T细胞能够有效迁移到滤泡区。 因此，ICOS信号在体内其实可以直接控制T细胞运动能力，直接决定它们在滤泡区组织中的迁移与分布。 图为通过双光子显微镜实时观察到 …

这类定位于滤泡区的CD4+ T细胞亚群被称作 滤泡辅助性T细胞 （follicular helper T cell，TFH），它们是体液免疫的重要调控细胞亚群，也是近年 细胞免疫学 的研究热点之一。

2016年6月2日 · 祁海教授指出，ICOSL（inducible T-cell co-stimulator ligand, also known as ICOSLG，诱导T细胞共刺激配体）不仅促进了TFH细胞发育，还调控了B细胞竞争性参与生发中心反应及形成浆细胞的过程。

When ICOS signaling is blocked, Tfh cells lose expression of characteristic Tfh genes and revert to an effector phenotype, resulting in disruption of the germinal center response. The co-stimulators ICOS (inducible T cell co-stimulator) and CD28 are both important for T follicular helper (TFH) cells, yet their individual contributions are unclear.