2024年12月25日 · IDH3A (Isocitrate Dehydrogenase (NAD(+)) 3 Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with IDH3A include Retinitis Pigmentosa 90 and D-2-Hydroxyglutaric Aciduria 2. Among its related pathways are Citric acid cycle (TCA cycle) and Metabolism of proteins.

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (IDH3α) is an enzyme that in humans is encoded by the IDH3A gene. [5] [6] Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These Enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the Other NADP (+).

2022年12月2日 · The nuclear-localized TCA cycle enzymes Pdha1, Pcb, Aco2, Cs, Idh3a promote somatic cell reprogramming and primed-to-naive transition. In addition, nuclear-localized TCA cycle enzymes,...

idh3a 轴的鉴定为 hcc 的发病机制提供了新的见解，idh3a 轴可能代表了治疗 hcc 的新靶点。本研究表明，idh3a 可以通过诱导 mta1 表达上调 mta1 表达并促进 hcc 上皮间质转化 (emt)，从而促进细胞迁移和 hcc 细胞的侵袭。在这里，我们证明了 idh3a 在 hcc 进展中的重要性。

This study highlights the importance of including this rarely-mutated gene in the molecular diagnostic set-ups for inherited retinal degenerations, and further delineates the phenotypic spectrum elicited by mutations in IDH3A. The silencing of IDH3a significantly delayed tumor growth by suppressing the HIF-1-mediated Warburg effect and ...

通过线粒体相关化合物筛选，我们发现美国 FDA 批准的 异柠檬酸脱氢酶 2 （IDH2）抑制剂 enasidenib 可增强记忆 CAR T 细胞的形成，并维持体内抗白血病细胞毒性。 从机理上讲，IDH2通过 磷酸戊糖途径 抑制葡萄糖的利用，从而减轻氧化应激，尤其是在营养受限的条件下，从而阻碍CAR T细胞的代谢能力。 此外，IDH2 还能限制细胞膜乙酰-CoA 水平，防止 组蛋白乙酰化，从而促进记忆细胞的形成。 在临床前模型中，结合药理 IDH2 抑制，CAR T 细胞疗法被证明具有 …

2025年2月9日 · Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+).

Here, we uncover a role for isocitrate dehydrogenase 3a (idh3a), a Krebs cycle enzyme, in neurotransmission. Loss of idh3a leads to a reduction of the metabolite, alpha-ketoglutarate (αKG), causing defects in synaptic transmission similar to the loss of syt1.

IDH3A的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为异柠檬酸脱氢酶催化异柠檬酸的氧化脱羧到2-酮戊二酸。 这些酶属于两个不同的亚类，其中一个利用NAD（+）用作电子受体和其它NADP（+）。 五异柠檬酸脱氢酶已经报道：三位NAD（+） - 依赖的异柠檬酸脱氢酶，其定位于线粒体基质，和两个NADP（+） - 依赖的异柠檬酸脱氢酶，其中之一就是线粒体和其他主要胞质。 NAD（+） - 依赖的异柠檬酸脱氢酶催化三羧酸循环的变构调 …