IFIT proteins (Interferon Induced proteins with tetratricopeptide repeats) are produced in the human body and are supposed to confer immunity against viral infections. These proteins are generally produced during viral infection by interferon ( IFN ) treatment as well as during pathogen recognition ( Pathogen associated molecular pattern ...

2025年2月9日 · Expression of interferon induced protein with tetratricopeptide repeats 5 (IFIT5) is positively correlated with pathological characteristics, and predicts a poor prognosis of bladder cancer patients. IFIT5 promotes SeV-induced IKK phosphorylation and NF-kappaB activation by regulating the recruitment of IKK to TAK1.

2024年12月25日 · IFIT5 (Interferon Induced Protein With Tetratricopeptide Repeats 5) is a Protein Coding gene. Diseases associated with IFIT5 include Zika Virus Congenital Syndrome and Microphthalmia With Limb Anomalies. Among its related pathways are Cytokine Signaling in Immune system and Antiviral mechanism by IFN-stimulated genes.

In this study, we reported that both the mRNA and protein levels of IFIT5 are up-regulated in response to RNA virus infection or polyinosinic-cytidylic acid stimulation. Ectopic expression of IFIT5 could synergize IRF3- and NF-κB-mediated gene expression, whereas knockdown of IFIT5 impairs the transcription of these genes.

2021年5月1日 · IFN-induced protein with tetratricopeptide repeats (IFITs), known as canonical IFN-stimulated genes (ISGs), play critical roles in regulating immune responses against pathogens and maintaining homeostasis. How the IFIT5 regulates innate immune responses is rarely reported and remains enigmatic.

IFIT5, also named as Interferon-induced 58 kDa protein or RI58, is a 482 amino acid protein, which contains eight TPR repeats and belongs to the IFIT family. IFIT5 localizes in the Cell projection. Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a ...

2019年3月15日 · In this study, we demonstrate that IFNγ can induce epithelial-to-mesenchymal transition (EMT) in prostate cancer cells via the JAK–STAT signaling pathway, leading to the transcription of IFN-stimulated genes (ISG) such as IFN-induced tetratricopeptide repeat 5 (IFIT5).

Invitrogen Human IFIT5 (aa 385-441) Control Fragment Protein, Catalog # RP-97124. Tested in Blocking Assay (BLOCK) and Control (Ctrl) applications. Supplied as 100 µL purified protein (≥5.0 mg/mL).

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