2024年12月25日 · IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) is a Protein Coding gene. Diseases associated with IFIT1 include Microphthalmia With Limb Anomalies and Chilblain Lupus. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in Immune system.

Interferon-induced protein with tetratricopeptide repeats 1 is a protein that in humans is encoded by the IFIT1 gene. [4] [5] [6]

IFIT1 is an IFN-induced highly expressed protein that functions in the cytoplasm as a dual sensor and effector molecule to restrict virus infection. You might find these chapters and articles relevant to this topic.

ifit1是一种高度诱导的具有四肽重复序列的干扰素刺激基因家族(isgs)成员，主要存在于细胞质，其表达受干扰素(ifn)、多种病毒和某些病原体相关分子模式的调节，具有抗病毒、抗炎等作用。

2012年12月14日 · This report showed that IFIT1 binds to the free 5′-ppp moiety on viral RNA from vesicular stomatitis virus, Rift Valley fever virus and influenza A virus and inhibits their infection by forming...

2011年6月5日 · Nature Immunology - The antiviral protein IFIT1 is upregulated substantially in the cytoplasm of virus-infected cells. Superti-Furga and colleagues show that IFIT1 is part of a...

Data show that interferon-induced proteins with tetratricopeptide repeats 1 and 2 (IFIT1 and IFIT2) contribute to the regulation of hepatitis B virus (HBV) replication, likely at both transcriptional and posttranscriptional steps. IFIT1 is not a dominant restriction factor against three different families of negative-sense RNA viruses.

该基因编码一种含有四肽重复序列的蛋白质，最初被鉴定为在干扰素处理后被诱导产生。 编码的蛋白质可以抑制病毒复制和翻译起始。 该基因与其他五个密切相关的基因位于 10 号染色体上的一个簇中。 该基因在 13 号染色体上有一个假基因。 已经观察到编码多种亚型的可变剪接转录物变体。 [RefSeq 提供，2012 年 8 月] This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon.

Our understanding of the antiviral actions of IFIT1, one of the most strongly induced interferon stimulated genes (ISGs), has advanced remarkably within the last few years. This review focuses on the recent cellular, biochemical, and structural discoveries that have provided new insight as …

IFIT1是一种高度诱导的具有四肽重复序列的干扰素刺激基因家族 (ISGs)成员,主要存在于细胞质,其表达受干扰素 (IFN)、多种病毒和某些病原体相关分子模式的调节,具有抗病毒、抗炎等作用。 IFIT1的抗病毒作用可通过多种机制和途径发挥,同时部分病毒也进化出独特的机制逃避宿主IFIT1的限制作用,从而对抗机体抗病毒免疫。 在许多炎症性疾病中,IFIT1也显示出其独特的抗炎作用。 该文就IFIT1的抗炎和. IFIT1是一种高度诱导的具有四肽重复序列的干扰素刺激基因家族 (ISGs)成 …