2024年12月25日 · IFNB1 (Interferon Beta 1) is a Protein Coding gene. Diseases associated with IFNB1 include Multisystem Inflammatory Syndrome In Children and Secondary Progressive Multiple Sclerosis . Among its related pathways are Overview of interferons-mediated signaling pathway and SARS-CoV-2 Infection .

Interferon beta is a protein that in humans is encoded by the IFNB1 gene. [5] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties. Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.

关于 ifnb1 Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:21,077,104-21,077,942 (from NCBI) This gene has 1 transcript (splice variant), 305 orthologues and 16 paralogues.

2025年2月8日 · HIV-1 replication upregulates the expression of MX2 and IFNB1 mRNA 24 hours after infection in monocyte-derived Langerhans cells: PubMed

20世纪50年代首次发现 i型干扰素 ，1965年首次发现 ii型干扰素 ，2003年，两个研究组分别报告发现了三种新的干扰素样细胞因子，分别称为 ifnλ1 、λ2和λ3或 白细胞介素-29 （il-29）、il-28a和il-28，构成 iii型干扰素 。 两个研究小组还鉴定了新的受体 ifnλr1 （也称为il-28ra），这些细胞因子通 …

小鼠 Mouse Ifnb1 靶点分子功能（预测） Enables cytokine activity and type I interferon receptor binding activity. Involved in B cell proliferation; cellular response to virus; and type I interferon signaling pathway.

ifn分为三种类型i型、ii型和iii型。其中i型ifn家族成员最多，在人类中编码13个部分同源的 ifnα 亚型（在小鼠中编码14个），一个 ifnβ 和几个定义不清的单基因产物（ifnε、ifnτ、ifnκ、ifnω、ifnδ和ifnζ）。 ii型ifn家族由单一基因产物 ifnγ 组成，主要由t细胞和自然杀伤（nk）细胞产生，能作用于 …

The dsRNA binding protein ILF3 as an essential host factor required for efficient translation of the central antiviral cytokine, IFNB1, and a subset of interferon-stimulated genes. These results reveal an interplay between IL-21 and type I IFN in the innate immune response to methicillin resistant Staphylococcus aureus.

2025年2月8日 · Interferon stimulated genes are activated by IFNb1-independent pathway in West Nile virus Eg101-infected mouse cells. Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2. Findings show that tumor cells can be induced through the toll-like receptor 4 (TLR4) pathway to produce interferon beta (IFNbeta) and positively ...

Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1). [provided by Alliance of Genome Resources, Apr 2022]