Interferon gamma (IFN-γ) is a type II interferon and is crucial for innate and adaptive immunity against intracellular pathogens including viruses (Schoenborn and Wilson, 2007). The function …

2024年12月25日 · IFNGR1 (Interferon Gamma Receptor 1) is a Protein Coding gene. Diseases associated with IFNGR1 include Immunodeficiency 27A and Immunodeficiency 27B. Among …

The IFN-γ receptor (IFNGR) is a member of the class II cytokine receptor family and is expressed at moderate levels on nearly every cell type, except mature erythrocytes. The receptor is …

2013年9月2日 · The nanoscale organization of the IFNGR complex plays a key role in JAK/STAT signaling. At steady state, interferon γ receptor subunits 1 and 2 (IFNGR1 and IFNGR2) are …

2018年6月19日 · IFNγ is a cytokine that is primarily produced by cells of the immune system, including innate-like lymphocyte populations, such as natural killer (NK) cells and innate …

2023年6月1日 · Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in mediating an array of immune responses including promotes antiviral activity, facilitates …

Gene ID: 3459, updated on 8-Feb-2025. This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer …

2021年8月12日 · In this review, we summarize recent advances in the epigenetic, genetic, and functional integrity of the IFNγ signaling pathway in the colorectal cancer microenvironment …

IFNγ ligates a heterodimeric cell surface receptor, the interferon gamma receptor (IFNGR), comprising ligand-binding IFNGR1 and signal-transducing IFNGR2 proteins . Ligation of the …

In this review, we summarize the potential mechanisms of IFN-γ resistance occurring at two critical stages: disrupted signal transduction along the IFNG/IFNGR/JAK/STAT pathway, or …