2024年12月25日 · This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection.

II型干扰素受体（IFNGR）分为配体吸附链（IFNGR1）和附属链（IFNGR2），两者都属于细胞因子II类受体超家族。 IFNGR复合物广泛分布于各种细胞和组织中。 IFNGR1与配体结合具有高特异性，但只有与IFNGR2共同存在时，II型干扰素（即IFNγ）才能诱导与IFNγ相关的信号传导和活性。 IFNγ主要由活化的T细胞和NK细胞产生，是淋巴因子的一种。 IFN-γ可以以细胞外基质相连的形式存在，故通过旁邻方式控制细胞生长，其可以分布在除成熟红细胞以外的几乎所有细胞表面。 …

Interferon gamma receptor 2 also known as IFN-γR2 is a protein which in humans is encoded by the IFNGR2 gene. [5] This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a multimer of two IFN-γR1 chains (encoded by IFNGR1) and two IFN-γR2 chains. [6]

ii型干扰素受体（ifngr）分为配体吸附链（ifngr1）和附属链（ifngr2），两者都属于细胞因子ii类受体超家族。ifngr复合物广泛分布于各种细胞和组织中。

2018年12月11日 · 该研究表明血管上皮的E-selectin通过与巨噬细胞膜上的配体结合激活BTK分子，BTK对IFN-γR2 Y289磷酸化，促进IFN-γR2与EFhd2的结合，进而促进IFN-γR2从高尔基体到细胞膜的转运过程。 我们的研究对于细胞因子受体的膜表面表达过程提供新的视角，并且对于治疗感染性疾病，自身免疫性疾病和肿瘤免疫提供了潜在的作用靶点。

2025年1月4日 · This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection.

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial Infection .

IFNGR2 is a prognostic marker in Cervical squamous cell carcinoma and endocervical adenocarcinoma, Colon adenocarcinoma, Kidney renal clear cell carcinoma

2018年11月15日 · Our findings demonstrate that membrane translocation of cytoplasmic IFN-γR2 is required to activate macrophage innate response against intracellular bacterial infection, identifying the assembly of functional cytokine receptors on cell membrane as an important layer in innate activation and cytokine signaling.

1 天前 · Although most cells express IFNGR1, IFNGR2 synthesis is not ubiquitous, being the limiting factor in sustaining signaling . Binding of an IFN-γ dimer to two IFNGR1 chains triggers the association of two IFNGR2 chains, leading to the formation of a 2:2:2 signaling complex, activating Janus kinases (JAKs) prior to the phosphorylation of STAT1 ...