2021年10月1日 · The IgE BCR has emerged as a critical B cell-intrinsic regulator of IgE responses through its antigen-independent signaling and low surface expression, predisposing …

2024年9月10日 · BCR triggering is the very first molecular event that ‘translates’ extracellular antigen binding to intracellular signalling. This intracellular signalling is BCR signalling, and it...

2021年12月7日 · Overall, our genome-wide CRISPR screens indicate that the chronic dynamics of IgE-BCR signaling translates into a distinct quality of calcium signaling in IgE + B cells and …

4 天之前 · Using fluorescent reporter mice for B cells poised to switch to IgE, we identified lung-resident allergen-specific IgG1 + MBCs as the major source of IgE-switching cells. B cell …

2016年12月9日 · Here we reveal that IgE + B cells are constrained by chronic activity of the IgE B cell receptor (BCR). In the absence of cognate antigen, the IgE BCR promoted terminal …

2024年12月1日 · IgE GC cells are unfit: they are highly apoptotic, express low levels of the B cell receptor (BCR) and various co-stimulatory molecules, and are under-represented in the light …

2019年4月18日 · Recent studies indicate that the IgE BCR has distinct signaling properties from the IgG1 BCR; in the absence of antigen, the IgE BCR seems to have increased basal …

3 天之前 · 芝加哥洛约拉大学Yee Ling Wu研究小组报道了肺驻留记忆B细胞维持呼吸道的过敏性IgE反应。 ... 肺中主要的IgE类别转换，并鉴定出IgG1 + MBCs是产生IgE的细胞的前体，这得 …

B cell-intrinsic regulation of IgE is orchestrated by the IgE B Cell Receptor (BCR). Through its antigen-independent signaling and low surface expression, the IgE BCR drives IgE B cells to …

2015年8月10日 · We observed that IgM-BCR activation is dependent on mechanical forces and exhibits a multi-threshold effect. In contrast, the activation of isotype-switched IgG- or IgE-BCR …