2018年11月30日 · Autoreactive IgG and IgM can be produced in warm AIHA; when bound to the erythrocyte, both are able to bind C1q and activate the classical complement pathway. C1 esterase inhibitor (C1-INH) is a commercially available inhibitor of the classical pathway licensed for hereditary angioedema with a favorable safety profile.

2021年3月11日 · Warm autoimmune hemolytic anemia (wAIHA) is the most prevalent form of autoimmune hemolytic anemia (AIHA), accounting for 60% to 70% of all cases. It is usually due to an immunoglobulin G (IgG) autoantibody that may activate complement (C) if present at high titer or if IgG1 and IgG3 subclasses are prevalent.

自身免疫性溶血性贫血（Autoimmune hemolytic anemia，AIHA）系体内免疫功能调节紊乱，产生自身抗体和（或）补体吸附于红细胞表面，通过抗原抗体反应加速红细胞破坏而引起的一种溶血性贫血。

2024年11月1日 · In wAIHA, IgG autoantibody reacts with autologous RBCs at 37 °C, leading to antibody-dependent cell-mediated cytotoxicity and increased phagocytosis of RBCs in the spleen. Cold AIHAs include cold...

Immune hemolytic anemia (IHA) is the clinical condition in which antibodies of immunoglobulin G (IgG) and/or immunoglobulin M (IgM) bind to red cell surface antigens and initiate red cell destruction via the complement system and the reticulo-endothelial system.

2021年10月6日 · Mixed warm antibody–mediated and cold antibody–mediated AIHA is defined by the presence of warm IgG autoantibodies combined with high-titer cold agglutinins. 6,38 The...

自身免疫性溶血性贫血 (AIHA) 定义为通过自身免疫机制对红细胞的破坏增加导致的贫血，通常由针对红细胞表面抗原的自身抗体所介导。 在过去的十年中，很少有关于病因、发病机制、诊断和治疗的重要新发现。 从历史上看…

Autoimmune haemolytic anaemia (AIHA) is a rare autoimmune disease characterised by haemolysis associated with the presence of immunoglobulins (Ig)G, IgM, or IgA and/or components of the complement system on red blood cells (RBCs), usually demonstrated by a positive direct antiglobulin test (DAT).

2024年4月12日 · (1) Warm-antibody AIHA (wAIHA) exhibits a pan-reactive IgG autoantibody recognizing a portion of band 3 (wherein the DAT may be positive with IgG, C3d or both). Treatment involves glucocorticoids and steroid-sparing agents and may consider IVIG or monoclonal antibodies to CD20, CD38 or C1q.

定义：自身免疫性溶血性贫血（autoimmune hemolytic anemia，AIHA）系体内B淋巴细胞免疫调节紊乱，产生自身抗体和（或）补体，并结合于红细胞膜上，致红细胞破坏加速而引起的一组溶血性贫血。