胰岛素样生长因子（insulin like growth factor，IGF）是一组具有促生长作用的多肽类物质，其分泌细胞广泛分布在人体肝、肾、肺、心、脑和肠等组织中。 IGF族有IGF-Ⅰ和IGF-Ⅱ两种。 IGF-Ⅰ的产生更依赖于GH，其促生长作用强，是儿童期的重要生长因子。 各组织中合成的IGF-Ⅰ多以自分泌或旁分泌方式发挥其促生长的作用，而肝脏所合成的IGFⅠ则进入血循环，以内分泌方式作用于靶细胞。 体内IGF-Ⅰ水平受GH的调控，IGF-Ⅰ对GH的分泌亦具有负反馈调节作用，IGF-Ⅱ …

2022年6月1日 · 根据以往研究，IGF1R是一种跨膜酪氨酸蛋白激酶受体，其配体是相对广谱的，insulin、IGF-1和IGF-2均可结合IGF1R，激活其下游信号传导。与IGF-1相比，IGF-2与IR-A的亲和力更高，IR-A的激活是促进有丝分裂。

Insulin-like growth factor 2 (IGF-2, at times IGF-II) is thought to be a primary growth factor required for early development while IGF-1 expression is required for achieving maximal growth. Gene knockout studies in mice have confirmed this, though other animals are likely to regulate the expression of these genes in distinct ways.

Similarly to IGF-1, IGF-2 is mainly produced in the liver and after it is released into circulation, it stimulates growth and cell proliferation. IGF-2 is thought to be a fetal growth factor, as it is essential for a normal embryonic development and is highly expressed in …

Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like and mitogenic activities.

Insulin-like growth factor-2 (IGF-2) is a protein closely related to IGF-1 and capable of binding to the IGF-1R as well as its own IGF-2 receptor (IGF-2R). However, whilst the IGF-1R is capable of signal transduction, the IGF-2R is not and binding results in lysosomal degradation of IGF-2.

The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states.

2017年4月9日 · Insulin-like growth factor-1 (IGF-1) and IGF-2 are circulating peptide growth factor hormones important in normal growth and development. Their biological effects are mediated by specific cell surface receptors, the type I IGF receptor (IGF1R) and the insulin receptor.

IGF-II is unique in that it can activate both IGF-1R and IR-A to promote cell growth and survival. However, of the three ligands, the molecular mechanisms underlying IGF-II action are the least understood. For this reason, this review will focus on IGF-II.

IGF有 IGF-1 和 IGF-2 两种，IGF-2主要对胎儿生长起作用，而儿童及成人体内起主要作用的、也是我们平常关注多的是IGF-1，IGF-1的产生依赖于 生长激素 水平，是生长激素刺激机体生长和代谢的主要调节因子。 IGF-1是一种生长激素介质，它是生长激素产生的生理过程中必须使用的一种活性蛋白多肽物质。 IGF-1具有降血糖、降血脂、舒张血管、促进骨代谢、维持骨骼正常结构和功能的功能。 此外，IGF1还能促进生长，促进细胞分化，并参与伤口愈合过程. IGF-1 (胰岛素样 …