Insulin-like growth factor 1 receptor - Wikipedia
IGF-1 binds to at least two cell surface receptors: the IGF1 Receptor (IGFR), and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor—it binds IGF-1 at …
胰岛素(Insulin)及其受体家族 - 知乎 - 知乎专栏
胰岛素受体家族成员在与各自的配体（如胰岛素 (insulin)、胰岛素样生长因子 ( IGF-1或IGF-2)）结合后，通过一系列的结构构象变化，激活胞内酪氨酸激酶，起始胞内信号传导，在生物体内发 …
Insulin Receptor Isoforms and Insulin Growth Factor-like ... - MDPI
2023年10月9日 · Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) have been reportedly linked to carcinogenesis and chemoresistance. While IRs serve as key …
胰岛素样生长因子 - 百度百科
胰岛素样生长因子（insulin like growth factor，IGF）是一组具有促生长作用的多肽类物质，其分泌细胞广泛分布在人体肝、肾、肺、心、脑和肠等组织中。 IGF族有IGF-Ⅰ和IGF-Ⅱ两种。 IGF …
The critical roles of IGFs in immune modulation and inflammation
2024年11月1日 · IGFs modulate macrophage phenotype and function, promoting anti-inflammatory responses and tissue repair. IGFs regulate T cell development, function, and …
胰岛素受体亚型和胰岛素生长因子样受体：对细胞信号传导、癌发 …
该综述强调了 ir 和 igfr 之间复杂的相互作用，导致抗 igfr 药物产生耐药性。 因此，两种受体的双重靶向可能为克服化疗耐药性提供更有效的策略。 总之，这篇综述揭示了 IR 和 IGFR 在细胞信 …
The insulin-like growth factor and its players: their functions ...
2022年9月2日 · Insulin-like growth factor (IGF) has unique and well-known functions in female fertility, according to documents reporting improved yield of oocytes, reinforced quality of the …
胰岛素样生长因子 1 受体（IGF1R）基因 - MCE-生物活性 ...
This gene has 17 transcripts (splice variants), 276 orthologues, 53 paralogues and is associated with 4 phenotypes. Ubiquitous expression in kidney (RPKM 8.9), ovary (RPKM 8.7) and 24 …
Real-time measurement in living cells of insulin-like growth factor ...
2005年6月15日 · The biological effects of the IGFs are mediated by the IGF-I receptor (IGFR), a covalent homodimer composed of two alpha and two beta chains, similar in structure to the …
Nat Commun：揭示胰岛素样生长因子受体IGF1R激活的分子机制
2019年10月13日 · 一型胰岛素样生长因子受体（Type 1 insulin-like growth factor receptor， IGF1R）属于受体酪氨酸激酶家族（receptor tyrosine kinases， RTKs），胰岛素受体亚家 …