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243.4K likes, 985 comments. “Ihh nggak kerasa kamu udah gede lagi aja🥹”

Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity)..

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Enables patched binding activity. Involved in several processes, including heart looping; positive regulation of smoothened signaling pathway; and regulation of T cell differentiation. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of biosynthetic process.

Recombinant Human Hedgehog Homolog, Indian (IHH) is a purified Prokaryotic Protein. Purity: >90% by SDS-PAGE. Host: E. coli. Endotoxin Level: 1.0EU per 1ug, by the LAL method.

Hedgehog 家族蛋白是必不可少的分泌信号分子，可调节各种发育过程，包括生长、模式形成和形态发生。 由该基因编码的蛋白质在骨骼生长和分化中特别起作用。 该基因的突变是导致 A1 型短指畸形的原因，其特征是手指和脚趾缩短或畸形。 该基因的突变也是导致顶头股骨发育不良的原因。 [RefSeq 提供，2015 年 11 月] This gene encodes a member of the Hedgehog family of proteins.

Dec 1, 2020 · In the IHH signaling pathway, patched receptor (PTC) suppresses the activity of smoothened receptor (SMO) by triggering degradation or intracellular vesicle trafficking. When IHH ligand binds to PTC, SMO is activated for downstream transcription of IHH target genes, such as …

Jul 3, 2020 · Ihh plays an important role in bone development and maintains bone balance before and after birth. Activation of Ihh has been reported to promote chondrocyte hypertrophy in human osteoarthritic cartilage and cultured chicken chondrocytes .