IκB kinase ε (IKKε): a therapeutic target in inflammation ... - PubMed
2013年4月1日 · Studies with IKKε knockout mice have illustrated a key role for IKKε in inflammatory and metabolic diseases. In this review we will highlight the mechanisms by which …
IKKε and TBK1 prevent RIPK1 dependent and independent
2024年1月2日 · Here we show that IKKε compensates for the loss of TBK1 kinase activity to prevent RIPK1-dependent and -independent inflammation in mice. Combined inhibition of IKKε …
IKBKE - Wikipedia
It is a Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also …
IKKε and TBK1 are essential components of the IRF3 signaling
2003年4月14日 · Here we report that the noncanonical IκB kinase homologs, IκB kinase-ε (IKKε) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-κB activation, are …
IKK - 百度百科
IKK是一种常见的 转录因子 激活蛋白 [1]，可以被位于 细胞质膜 的 TNF -TNFR复合体、 IL -ILR复合体、活化的 Toll样受体 、 病毒感染 和胞外电离辐射激活。 常见的 炎症因子 (包括IL-α …
IKBKE Gene - GeneCards | IKKE Protein | IKKE Antibody
2024年12月25日 · IKBKE (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon) is a Protein Coding gene. Diseases associated with IKBKE include Hematologic Cancer and …
IκB kinase ɛ (IKKɛ): A therapeutic target in inflammation and cancer
Studies with IKKɛ knockout mice have illustrated a key role for IKKɛ in inflammatory and metabolic diseases. In this review we will highlight the mechanisms by which IKKɛ impacts on signaling …
Factor inhibiting HIF negatively regulates antiviral innate immunity ...
2024年1月23日 · Here, we show that factor inhibiting hypoxia-inducible factor (HIF) (FIH), an asparaginyl hydroxylase, interacts with IKKϵ and catalyzes asparagine hydroxylation of IKKϵ at …
IKB激酶IKKε的研究进展.pdf 3页 - 原创力文档
2018年5月9日 · 最新研究发现IKKe可 以促进这一通路，说明了 silon)，该基因定位于lq32，包括N端激酶区域，类泛 IKK．6在调节IL-17反应中所起的作用[91。IKKe主要 素区域、C端LZ结构 …
核因子 kappa B 激酶亚基 epsilon 抑制因子（IKBKE）基因 - MCE
IKBKE 是一种非经典 I-kappa-B (参见 MIM 164008) 激酶 (IKK) ，对于调节抗病毒信号通路至关重要。 IKBKE 也被确定为乳腺癌 (MIM 114480) 致癌基因，并且在超过 30% 的乳腺癌和乳腺癌 …